Results 101 to 110 of about 1,025,211 (292)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

IMPLEMENTASI PROBLEM-BASED LEARNING BERDASARKAN INDEPENDENSI BELAJAR UNTUK MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH DENGAN MENGONTROL KECEMASAN MATEMATIS

Aksioma: Jurnal Program Studi Pendidikan Matematika
Penelitian ini didasarkan atas masalah rendahnya kemampuan siswa dalam memecahkan masalah matematis. Tujuan penelitian ini adalah peningkatan kemampuan siswa dalam penyelesaian masalah melalui penerapan model Problem-Based Learning (PBL) berdasarkan ...
Helfra Durasa, Ni Made Sri Mertasari, I Gusti Ngurah Pujawan   +2 more
doaj   +1 more source

Eksperimentasi Model Pembelajaran Kooperatif Tipe Team Assisted Individualization Guide Note Taking (TAI GNT) Ditinjau dari Kemandirian Belajar Siswa

Jurnal Elemen, 2015
The aim of the research was to determine the effect of learning models on mathematics learning achievement viewed from students independence learning. The learning models compared were cooperative learning model of TAI GNT, cooperative learning model of ...
Muhammad Gazali
doaj   +1 more source

Active Learning: Self-directed Learning and Independent Work

, 2000
0ntbrkt;
Hout-Wolters, B., Simons, R.J., Volet, S.   +2 more
openaire   +3 more sources

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Development of An Interactive E-Module Based on Blended Learning to Enhance Student Independence and Learning Outcomes

Jurnal Kependidikan
This study aims to analyze the feasibility and effectiveness of interactive e-modules based on blended learning to increase independence and learning outcomes on acid-base materials. This research is development research using the Borg & Gall model which
Novia Andriani, Kusumawati Dwiningsih
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

A Double Machine Learning Approach to Estimate the Effects of Musical Practice on Student's Skills

, 2018
This study investigates the dose-response effects of making music on youth development. Identification is based on the conditional independence assumption and estimation is implemented using a recent double machine learning estimator.
Knaus, Michael C.
core  

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source