Results 51 to 60 of about 258,548 (313)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Technical Evaluation Report 40: The International Learning Object Metadata Survey

open access: yesInternational Review of Research in Open and Distributed Learning, 2004
A wide range of projects and organizations is currently making digital learning resources (learning objects) available to instructors, students, and designers via systematic, standards-based infrastructures.
Norm Friesen
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Content-driven design and architecture of E-learning applications [PDF]

open access: yes, 2008
E-learning applications combine content with learning technology systems to support the creation of content and its delivery to the learner. In the future, we can expect the distinction between learning content and its supporting infrastructure to become
Pahl, Claus
core   +1 more source

Transposing MISA Learning Scenarios into IMS Units of Learning

open access: yesJournal of Interactive Media in Education, 2005
Commentary on: Chapter 17: Applying Learning Design to Supported Open Learning. (McAndrew & Weller, 2005) Abstract: This paper reports an exploratory study investigating the transposition process of a course called the Black Box into a Unit of Learning (
Ileana de la Teja   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

An innovative use of learning objects and learning style in pedagogic agent systems [PDF]

open access: yes, 2005
Adaptivity in education is increasingly demanded in order to improve the efficiency and effectiveness of the learning process, but few intelligent learning systems exist which are dynamic and able to provide personalized learning materials to satisfy ...
Sun, Shanghua   +2 more
core  

From Cognitive Landscapes to Digital Hyperscapes

open access: yesInternational Review of Research in Open and Distributed Learning, 2003
The widespread diffusion of e-Learning in organizations has encouraged the discovery of more effective ways for conveying digital information to learners, for instance, via the commonly called Learning Management Systems (LMS).
José Bidarra, Ana Dias
doaj  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Learning objects, learning tasks and handhelds

open access: yes, 2008
The main idea behind learning objects is that they are to exist as digital resources separated from the learning task in which they are used. This allows a learning object to be reused with different learning tasks.
Churchill, D, Hedberg, JG
core   +1 more source

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