Results 81 to 90 of about 3,709,753 (233)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
MICROSCOPICAL INVESTIGATION OF HERB GOLDENROD CANADENSIS (SOLIDAGO CANADENSIS L.)
Сеченовский вестник, 2017 Herbal drug products are widely used to replace or supplement traditional medicine. One of the promising plants with antibacterial and antinflammatory activity is the goldenrod - a member of the Asteraceae family.
F. Suleymanova +2 more
doaj
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Phytochemical Screening and Antibacterial Activity of Leaves Extract Balangla (Litsea cubeba (Lour) Pers.) from Malinau, East Borneo [PDF]
, 2015 Balangla (Litsea cubeba) plant is used as traditional medicine by Dayak Kenyah tribe in East Kalimantan. It contains active compounds that are efficient to treat many human diseases and believed to have an antibacterial activity. The purposes of
Manurung, Hetty +2 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 A comparative study of the biologically active compounds (BAC) composition of alcoholic extracts of leaves and fruits was carried out by GLC-MS. It is shown that the BAC composition of leaves of Hedera caucasica is more extensive: the structure of 22 ...
V. M. Baeva +2 more
doaj
Plant Production Science, 2019 Forty-seven lucerne varieties/lines were examined to quantify their morphological, production characteristics, and nutritive values in southeastern Australia.
Lili Nan +3 more
doaj +1 more source