Inhibition of the lectin pathway of complement activation reduces LPS-induced acute respiratory distress syndrome in mice [PDF]
Frontiers in Immunology, 2023 Acute respiratory distress syndrome (ARDS) is a life-threatening disorder with a high rate of mortality. Complement activation in ARDS initiates a robust inflammatory reaction that can cause progressive endothelial injury in the lung.
Youssif M. Ali +11 more
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Development and characterization of narsoplimab, a selective MASP-2 inhibitor, for the treatment of lectin-pathway–mediated disorders [PDF]
Frontiers in Immunology, 2023 IntroductionOveractivation of the lectin pathway of complement plays a pathogenic role in a broad range of immune-mediated and inflammatory disorders; mannan-binding lectin-associated serine protease-2 (MASP-2) is the key effector enzyme of the lectin ...
Thomas Dudler +2 more
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Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups [PDF]
Frontiers in Immunology, 2023 IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus.
Lisa Hurler +174 more
doaj +3 more sources
Dengue and the Lectin Pathway of the Complement System. [PDF]
Viruses, 2021 Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4).
Kraivong R +4 more
europepmc +7 more sources
Plasma Lectin Pathway Complement Proteins in Patients With COVID-19 and Renal Disease [PDF]
Frontiers in Immunology, 2021 We do not understand why non-white ethnicity and chronic kidney disease increase susceptibility to COVID-19. The lectin pathway of complement activation is a key contributor to innate immunity and inflammation.
Nicholas R. Medjeral-Thomas +23 more
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Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy [PDF]
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
doaj +3 more sources
Components of the Lectin Pathway of Complement in Haematologic Malignancies. [PDF]
Cancers (Basel), 2020 The complement system is activated cascadically via three distinct major routes: classical pathway (CP), alternative pathway (AP) or lectin pathway (LP).
Cedzyński M, Świerzko AS.
europepmc +5 more sources
Frontiers in Immunology, 2018 Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality in modern medicine. Early reperfusion accomplished by primary percutaneous coronary intervention is pivotal for reducing myocardial damage in ST elevation AMI.
Marten Trendelenburg +2 more
exaly +4 more sources
MAp34 Regulates the Non-specific Cell Immunity of Monocytes/Macrophages and Inhibits the Lectin Pathway of Complement Activation in a Teleost Fish [PDF]
Frontiers in Immunology, 2020 The lectin pathway of the complement system is one of the main components of innate immunity, which plays a pivotal role in the defense against infectious microorganisms and maintains immune homeostasis.
Liangliang Mu +5 more
doaj +3 more sources
Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases [PDF]
Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
doaj +3 more sources