Role of the lectin pathway of complement in hematopoietic stem cell transplantation-associated endothelial injury and thrombotic microangiopathy [PDF]
Experimental Hematology & Oncology, 2021 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) is a life-threatening syndrome that occurs in adult and pediatric patients after hematopoietic stem cell transplantation.
Eleni Gavriilaki +6 more
doaj +3 more sources
MAp34 Regulates the Non-specific Cell Immunity of Monocytes/Macrophages and Inhibits the Lectin Pathway of Complement Activation in a Teleost Fish [PDF]
Frontiers in Immunology, 2020 The lectin pathway of the complement system is one of the main components of innate immunity, which plays a pivotal role in the defense against infectious microorganisms and maintains immune homeostasis.
Liangliang Mu +5 more
doaj +3 more sources
Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases [PDF]
Frontiers in Immunology, 2018 The complement system has moved into the focus of drug development efforts in the last decade, since its inappropriate or uncontrolled activation has been recognized in many diseases.
József Dobó +2 more
doaj +3 more sources
Serine Proteases in the Lectin Pathway of the Complement System [PDF]
Proteases in Physiology and Pathology, 2017 The complement system plays a crucial role in host defense against pathogen infections and in the recognition and removal of damaged or altered self-components. Complement system activation can be initiated by three different pathways—classical, alternative, and lectin pathways—resulting in a proteolytic cascade, which culminates in multiple biological
Andrade F +3 more
europepmc +4 more sources
IgA nephropathy: the lectin pathway and implications for targeted therapy
Kidney International, 2023 Kidney international 104(2), 254-264 (2023).
Barratt, Jonathan +7 more
openaire +4 more sources
Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein [PDF]
Frontiers in ImmunologyComplement activation is considered to contribute to the pathogenesis of severe SARS-CoV-2 infection, mainly by generating potent immune effector mechanisms including a strong inflammatory response.
Isabelle Bally +15 more
doaj +2 more sources
Lectin complement pathway proteins in healthy individuals [PDF]
Clinical and Experimental Immunology, 2017 Summary Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more proteins, with the intention of uncovering the functions of the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal.
Kristian Stengaard-pedersen +2 more
exaly +6 more sources
The Lectin Pathway in Thrombotic Conditions—A Systematic Review [PDF]
Thrombosis and Haemostasis, 2018 AbstractThe lectin pathway of the complement system can activate the coagulation system in vitro, but the role of the lectin pathway in haemostatic activation and thrombosis in vivo is not clear. We performed a systematic review of the existing literature on associations between the lectin pathway and arterial and venous thrombosis, in accordance with ...
Julie Brogaard Larsen +3 more
openaire +5 more sources
Frontiers in Immunology, 2016 Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, K Pilely
exaly +3 more sources
Arthritis Research & Therapy, 2019 Background The role of the complement system in the pathogenesis of systemic sclerosis (SSc) is controversial. This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion injury in SSc.
Michael Osthoff +6 more
doaj +2 more sources