Components of the Lectin Pathway of Complement in Solid Tumour Cancers. [PDF]
Cancers (Basel), 2022 Simple Summary Cancer is a major cause of human deaths. The complement system is an important branch of the innate immune response that can be activated via three distinct pathways (classical, alternative, lectin). Complement activation may contribute to
Cedzyński M, Świerzko AS.
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Inhibition of the lectin pathway of complement ameliorates hypocomplementemia and restores serum bactericidal activity in patients with severe COVID-19. [PDF]
Clin Transl Med, 2022 Dear Editor, Complement activation is a key mediator of thrombosis, inflammation and tissue damage during acute SARS-CoV2 infection. Complement components are depleted during acute infection, and the proinflammatory anaphylatoxins C3a and C5a, which play
Lynch NJ +8 more
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Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins. [PDF]
Front Immunol, 2021 Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Ali YM +8 more
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Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs. [PDF]
Front Immunol, 2022 The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Hurler L +12 more
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Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality. [PDF]
Front Immunol, 2021 Background The SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Defendi F +15 more
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Critical role of lectin pathway mediated by MBL-associated serine proteases in complement activation for the pathogenesis in systemic lupus erythematosus [PDF]
Heliyon, 2023 In complement activation system, although the classical pathway has shown to play a critical role for the pathogenesis of SLE, the role of lectin pathway has remained unknown in the pathogenesis of SLE.
Yuko Asanuma +6 more
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The Lectin Pathway of the Complement System-Activation, Regulation, Disease Connections and Interplay with Other (Proteolytic) Systems. [PDF]
Int J Mol SciThe complement system is the other major proteolytic cascade in the blood of vertebrates besides the coagulation–fibrinolytic system. Among the three main activation routes of complement, the lectin pathway (LP) has been discovered the latest, and it is ...
Dobó J +5 more
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Serine Proteases in the Lectin Pathway of the Complement System [PDF]
Proteases in Physiology and Pathology, 2017 The complement system plays a crucial role in host defense against pathogen infections and in the recognition and removal of damaged or altered self-components.
Andrade F +3 more
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The Influence of the Lectin Pathway of Complement Activation on Infections of the Respiratory System. [PDF]
Front Immunol, 2020 Lung diseases are among the leading causes of morbidity and mortality. Complement activation may prevent a variety of respiratory infections, but on the other hand, could exacerbate tissue damage or contribute to adverse side effects. In this review, the
Świerzko AS, Cedzyński M.
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IgA Nephropathy: the Lectin Pathway and Implications for Targeted Therapy.
Kidney International, 2023 Kidney international 104(2), 254-264 (2023).
J. Barratt +7 more
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