Results 21 to 30 of about 2,474,660 (311)
The Lectin Pathway of Complement and Rheumatic Heart Disease [PDF]
Frontiers in Pediatrics, 2015 The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry.
Marcia Holsbach Beltrame +4 more
doaj +3 more sources
Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway. [PDF]
J Clin Immunol, 2020 Mannose-binding lectin (MBL)-associated serine protease-2 (MASP-2) is an indispensable enzyme for the activation of the lectin pathway of complement. Its deficiency is classified as a primary immunodeficiency associated to pyogenic bacterial infections ...
García-Laorden MI +16 more
europepmc +2 more sources
The Lectin Pathway in Thrombotic Conditions—A Systematic Review [PDF]
Thrombosis and Haemostasis, 2018 The lectin pathway of the complement system can activate the coagulation system in vitro, but the role of the lectin pathway in haemostatic activation and thrombosis in vivo is not clear.
J. Larsen, C. Hvas, A. Hvas
semanticscholar +5 more sources
Revisiting the interaction between complement lectin pathway protease MASP-2 and SARS-CoV-2 nucleoprotein [PDF]
Frontiers in ImmunologyComplement activation is considered to contribute to the pathogenesis of severe SARS-CoV-2 infection, mainly by generating potent immune effector mechanisms including a strong inflammatory response.
Isabelle Bally +15 more
doaj +2 more sources
Lectin complement pathway proteins in healthy individuals [PDF]
Clinical and Experimental Immunology, 2017 Summary Since the discovery of the lectin pathway of complement activation, numerous clinical cohorts have been examined for one or more proteins, with the intention of uncovering the functions of the proteins or with the aim of discovering new biomarkers or diagnostic tools. To unveil the abnormal, it is pivotal to know the normal.
Kristian Stengaard-pedersen +2 more
exaly +6 more sources
Frontiers in Immunology, 2016 Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear.
Anne Rosbjerg, Ninette Genster, K Pilely
exaly +3 more sources
Arthritis Research & Therapy, 2019 Background The role of the complement system in the pathogenesis of systemic sclerosis (SSc) is controversial. This study investigated the role of the lectin pathway of complement as a mediator of ischemia/reperfusion injury in SSc.
Michael Osthoff +6 more
doaj +2 more sources
Studies Into β-Glucan Recognition in Fish Suggests a Key Role for the C-Type Lectin Pathway. [PDF]
Front Immunol, 2019 Immune-modulatory effects of β-glucans are generally considered beneficial to fish health. Despite the frequent application of β-glucans in aquaculture practice, the exact receptors and downstream signalling remains to be described for fish.
Petit J +5 more
europepmc +2 more sources
Lectin pathway proteins of the complement system in normotensive pregnancy and pre‐eclampsia [PDF]
American Journal of Reproductive Immunology, 2019 The lectin pathway of the complement system may be involved in the pathogenesis of pre‐eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre ...
Julie Brogaard Larsen +6 more
openalex +2 more sources
Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation. [PDF]
J Biol Chem, 2019 ER protein 57 (ERp57), a thiol isomerase secreted from vascular cells, is essential for complete thrombus formation in vivo, but other extracellular ERp57 functions remain unexplored.
Eriksson O +6 more
europepmc +2 more sources