Results 21 to 30 of about 2,513,226 (377)

Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels. [PDF]

PLoS Neglected Tropical Diseases, 2020
BackgroundDeposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement.
Hellen Weinschutz Mendes, Angelica Beate Winter Boldt, Ewalda von Rosen Seeling Stahlke, Jens Christian Jensenius, Steffen Thiel, Iara J Taborda Messias-Reason   +5 more
doaj   +2 more sources

Components of the Lectin Pathway of Complement in Solid Tumour Cancers. [PDF]

Cancers (Basel), 2022
Simple Summary Cancer is a major cause of human deaths. The complement system is an important branch of the innate immune response that can be activated via three distinct pathways (classical, alternative, lectin). Complement activation may contribute to
Cedzyński M, Świerzko AS.
europepmc   +2 more sources

Inhibition of the lectin pathway of complement ameliorates hypocomplementemia and restores serum bactericidal activity in patients with severe COVID-19. [PDF]

Clin Transl Med, 2022
Dear Editor, Complement activation is a key mediator of thrombosis, inflammation and tissue damage during acute SARS-CoV2 infection. Complement components are depleted during acute infection, and the proinflammatory anaphylatoxins C3a and C5a, which play
Lynch NJ, Chan ACY, Ali YM, Khatri P, Bamigbola IE, Demopulos G, Paganessi M, Rambaldi A, Schwaeble WJ.   +8 more
europepmc   +2 more sources

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins. [PDF]

Front Immunol, 2021
Early and persistent activation of complement is considered to play a key role in the pathogenesis of COVID-19. Complement activation products orchestrate a proinflammatory environment that might be critical for the induction and maintenance of a severe ...
Ali YM, Ferrari M, Lynch NJ, Yaseen S, Dudler T, Gragerov S, Demopulos G, Heeney JL, Schwaeble WJ.   +8 more
europepmc   +2 more sources

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs. [PDF]

Front Immunol, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classical
Hurler L, Toonen EJM, Kajdácsi E, van Bree B, Brandwijk RJMGE, de Bruin W, Lyons PA, Bergamaschi L, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Sinkovits G, Cervenak L, Würzner R, Prohászka Z.   +12 more
europepmc   +2 more sources

Complement Alternative and Mannose-Binding Lectin Pathway Activation Is Associated With COVID-19 Mortality. [PDF]

Front Immunol, 2021
Background The SARS-CoV-2 infection triggers excessive immune response resulting in increased levels of pro-inflammatory cytokines, endothelial injury, and intravascular coagulopathy.
Defendi F, Leroy C, Epaulard O, Clavarino G, Vilotitch A, Le Marechal M, Jacob MC, Raskovalova T, Pernollet M, Le Gouellec A, Bosson JL, Poignard P, Roustit M, Thielens N, Dumestre-Pérard C, Cesbron JY.   +15 more
europepmc   +2 more sources

Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19. [PDF]

J Innate Immun, 2023
Götz MP, Skjoedt MO, Bayarri-Olmos R, Hansen CB, Pérez-Alós L, Jarlhelt I, Benfield T, Rosbjerg A, Garred P.   +8 more
europepmc   +3 more sources

Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression. [PDF]

Nat Cancer, 2021
Magrini E, Di Marco S, Mapelli SN, Perucchini C, Pasqualini F, Donato A, Guevara Lopez ML, Carriero R, Ponzetta A, Colombo P, Cananzi F, Supino D, Reis ES, Peano C, Inforzato A, Jaillon S, Doni A, Lambris JD, Mantovani A, Garlanda C.   +19 more
europepmc   +2 more sources

The Lectin Pathway of the Complement System-Activation, Regulation, Disease Connections and Interplay with Other (Proteolytic) Systems. [PDF]

Int J Mol Sci
The complement system is the other major proteolytic cascade in the blood of vertebrates besides the coagulation–fibrinolytic system. Among the three main activation routes of complement, the lectin pathway (LP) has been discovered the latest, and it is ...
Dobó J, Kocsis A, Farkas B, Demeter F, Cervenak L, Gál P.   +5 more
europepmc   +2 more sources

The role of the lectin pathway of the complement system in SARS-CoV-2 lung injury. [PDF]

Transl Res, 2021
Malaquias MAS, Gadotti AC, Motta-Junior JDS, Martins APC, Azevedo MLV, Benevides APK, Cézar-Neto P, Panini do Carmo LA, Zeni RC, Raboni SM, Fonseca AS, Machado-Souza C, Moreno-Amaral AN, de Noronha L.   +13 more
europepmc   +2 more sources