Results 11 to 20 of about 16,640 (230)

Sphingolipid degradation in Leishmania (Leishmania) amazonensis.

PLoS Neglected Tropical Diseases, 2012
BackgroundHuman leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species ...
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
doaj   +3 more sources

Cinnamides Target Leishmania amazonensis Arginase Selectively [PDF]

Molecules, 2020
Caffeic acid and related natural compounds were previously described as Leishmania amazonensis arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase.
Edson Roberto da Silva, Júlio Abel Alfredo dos Santos Simone Come, Simone Brogi, Vincenzo Calderone, Giulia Chemi, Giuseppe Campiani, Trícia Maria Ferrreira de Sousa Oliveira, Thanh-Nhat Pham, Marc Pudlo, Corine Girard, Claudia do Carmo Maquiaveli   +10 more
openaire   +4 more sources

Ethanolic extract of Croton blanchetianus Ball induces mitochondrial defects in Leishmania amazonensis promastigotes [PDF]

Anais da Academia Brasileira de Ciências, 2020
Leishmaniasis is a neglected disease caused by Leishmania. Chemotherapy remains the mainstay for leishmaniasis control; however, available drugs fail to provide a parasitological cure, and are associated with high toxicity. Natural products are promising
KATILY L.G. PEREIRA, NANCY B.R. VASCONCELOS, JULIANA V.C. BRAZ, JOB D.F. INÁCIO, CHARLES S. ESTEVAM, CRISTIANE B. CORREA, ROBERTA P.M. FERNANDES, ELMO E. ALMEIDA-AMARAL, RICARDO SCHER   +8 more
doaj   +1 more source

Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB/c mice against Leishmania (Leishmania) amazonensis infection [PDF]

, 2014
Background/Purpose: A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Garcia Bustos, Maria Fernanda, Morea, Gastón, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +1 more source

Identificação de espécies de Leishmania isoladas de casos humanos em Mato Grosso do Sul por meio da reação em cadeia da polimerase Identification of Leishmania species isolated in human cases in Mato Grosso do Sul, by means of the polymerase chain reaction

Revista da Sociedade Brasileira de Medicina Tropical, 2009
As leishmanioses são zoonoses endêmicas em Mato Grosso do Sul e têm por agentes etiológicos nessa região Leishmania (Leishmania) chagasi, Leishmania (Leishmania) amazonensis e Leishmania (Viannia) braziliensis.
Manoel Sebastião da Costa Lima Junior, Renato Andreotti, Maria Elizabeth Moraes Cavalheiros Dorval, Elisa Teruya Oshiro, Alessandra Gutierrez de Oliveira, Maria de Fatima Cepa Matos   +5 more
doaj   +1 more source

The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the golden hamster model A atividade da azitromicina contra a Leishmania (Viannia) braziliensis e a Leishmania (Leishmania) amazonensis no modelo golden hamster

Revista da Sociedade Brasileira de Medicina Tropical, 2007
New therapeutic alternatives against leishmaniasis remain a priority. The activity of azithromycin against Leishmania (Leishmania) major has been previously demonstrated.
Ángel Sinagra, Concepción Luna, David Abraham, Maria del Carmen Iannella, Adelina Riarte, Alejandro J. Krolewiecki   +5 more
doaj   +1 more source

Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis [PDF]

Natural Product Research, 2016
Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and Leishmania braziliensis. Additionally, a quantitative structure activity relationship has been made, since all these natural compounds were found to have potent to mild ...
A Sosa, Susana Amaya, Efraín Salamanca, Miguel Gilabert, Alicia Bardón, Alberto Giménez, Nancy Vera, Susana Borkosky   +7 more
openaire   +3 more sources

Impact of tumor necrosis factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania (Leishmania) amazonensis [PDF]

, 2014
Tumor necrosis factor (TNF) is involved in host resistance to several intracellular pathogens. Although the critical role of TNF receptor (TNFR)p55 in Leishmania (Leishmania) major infection has been demonstrated, the impact of TNFRp55 deficiency on L ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Di Genaro, María Silvia, Gea, Susana, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +1 more source

The Paradox of a Phagosomal Lifestyle: How Innate Host Cell-Leishmania amazonensis Interactions Lead to a Progressive Chronic Disease

Frontiers in Immunology, 2021
Intracellular phagosomal pathogens represent a formidable challenge for innate immune cells, as, paradoxically, these phagocytic cells can act as both host cells that support pathogen replication and, when properly activated, are the critical cells that ...
Matheus B. Carneiro, Nathan C. Peters
doaj   +1 more source

Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]

, 2017
Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson, Andrade-Neto, Antoine, Bansal, Berman, Blanchette-Mackie, Burack, Carstea, Carvalho, Chakraborty, Chattopadhyay, Collins, Coombs, Coppens, De Cicco, Desvergne, Duclos, Edwards, Ehrenman, Fernandes, Ghosh, Ghosh, Ghosh, Ginger, Ginger, Goldstein, Groener, Hamid, Hart, Ikonen, Infante, Johndrow, Kima, Kima, Kok, Kwon, Lal, Lecoeur, Lippuner, Livak, Majumder, Maxfield, McIntosh, Misslitz, Naureckiene, Neufeld, Osorio y Fortea, Ovalle-Bracho, Paape, Paape, Pereira, Portugal, Pucadyil, Rabhi, Redgrave, Roberts, Rosenzweig, Rub, Russell, Saunders, Sen, Shamshiev, Soares, Sorensen, Tetley, Tewary, Tontonoz, Weinheber   +67 more
core   +2 more sources