Results 41 to 50 of about 6,625 (182)

Leishmania amazonensis: Characterization of an ecto-phosphatase activity [PDF]

Experimental Parasitology, 2006
We have characterized a phosphatase activity present on the external surface of Leishmania amazonensis, using intact living parasites. This enzyme hydrolyzes the substrate p-nitrophenylphosphate (p-NPP) at the rate of 25.70+/-1.17 nmol Pi x h(-1) x 10(-7)cells. The dependence on p-NPP concentration shows a normal Michaelis-Menten kinetics for this ecto-
Elmo Eduardo, de Almeida-Amaral, Rodrigo, Belmont-Firpo, Marcos André, Vannier-Santos, José Roberto, Meyer-Fernandes   +3 more
openaire   +2 more sources

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source

DC-SIGN Mediates the Interaction Between Neutrophils and Leishmania amazonensis-Infected Dendritic Cells to Promote DC Maturation and Parasite Elimination

Frontiers in Immunology, 2021
BackgroundLeishmaniasis is a neglected arthropod-borne disease that affects millions of people worldwide. Successful Leishmania infections require the mitigation of immune cell functions leading to parasite survival and proliferation.
Rafael Tiburcio, Rafael Tiburcio, Léon Dimitri Melo, Léon Dimitri Melo, Sara Nunes, Sara Nunes, Ana Luísa Augusto Barbosa, Elaine Carvalho de Oliveira, Elaine Carvalho de Oliveira, Martha Suarez, Martha Suarez, Valéria M. Borges, Valéria M. Borges, Natalia Tavares, Natalia Tavares, Claudia Ida Brodskyn, Claudia Ida Brodskyn, Claudia Ida Brodskyn   +17 more
doaj   +1 more source

Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez‐Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +13 more
wiley   +1 more source

Efficacy of a diarylheptanoid derivative against Leishmania amazonensis [PDF]

Memórias do Instituto Oswaldo Cruz, 2003
The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial.
Luciana Vignólio Alves, Rosane Maria Temporal, Léa Cysne-Finkelstein, Leonor Laura Leon   +3 more
openaire   +4 more sources

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin’s lymphoma

Revista do Instituto de Medicina Tropical de São Paulo, 2022
Visceral leishmaniasis (VL) is mainly caused by Leishmania (Leishmania) donovani and Leishmania (L.) infantum; however, other Leishmania species have been associated with VL. We report a case of a patient simultaneously diagnosed with VL caused by Leishmania (L.) amazonensis and Hodgkin's lymphoma.
Victor Bertolo Gomes Porto, Laína Bubach Carvalho, Bruno Fernando Buzo, Marcelo Nobrega Litvoc, Ana Catharina S. Santos, Rafael Avila Rocci, Sandra Regina Castro Soares, Ricardo Andrade Zampieri, Maria Irma Seixas Duarte, José Angelo Lauletta Lindoso   +9 more
openaire   +3 more sources

The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis

Parasites & Vectors, 2017
Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani   +7 more
doaj   +1 more source

Multifunctional Oregano‐Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano‐derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications.
Jesus Romo‐Rico, Neethu Ninan, Andrew Hayles, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Richard Bright, Mohan Jacob   +7 more
wiley   +1 more source

Cinnamides Target Leishmania amazonensis Arginase Selectively [PDF]

Molecules, 2020
Caffeic acid and related natural compounds were previously described as Leishmania amazonensis arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase.
Edson Roberto da Silva, Júlio Abel Alfredo dos Santos Simone Come, Simone Brogi, Vincenzo Calderone, Giulia Chemi, Giuseppe Campiani, Trícia Maria Ferrreira de Sousa Oliveira, Thanh-Nhat Pham, Marc Pudlo, Corine Girard, Claudia do Carmo Maquiaveli   +10 more
openaire   +4 more sources