Fusion between Leishmania amazonensis and Leishmania major parasitophorous vacuoles: live imaging of coinfected macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2010 Protozoan parasites of the genus Leishmania alternate between flagellated, elongated extracellular promastigotes found in insect vectors, and round-shaped amastigotes enclosed in phagolysosome-like Parasitophorous Vacuoles (PVs) of infected mammalian ...
Fernando Real +2 more
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"Leishmania infantum" : molecular analysis for identification of potential virulence factors and genes of diagnostic use [PDF]
, 2004 Leishmania infantum is the causative agents of zoonotic visceral leishmaniasis, a fatal disease if left untreated. In Southern Europe, the number of HIV/Leishmania infantum co-infections is increasing and becomes an emerging concern for the public health.
Niederwieser, Igor
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Drosophila Model of Leishmania amazonensis Infection
BIO-PROTOCOL, 2017 This protocol describes how to generate and harvest antibody-free L. amazonensis amastigotes, and how to infect adult Drosophila melanogaster with these parasites. This model recapitulates key aspects of the interactions between Leishmania amastigotes and animal phagocytes.
Okuda, Kendi, Silverman, Neal
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Leishmania manipulation of sand fly feeding behavior results in enhanced transmission [PDF]
, 2007 In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (
Rogers, Matthew E, Bates, Paul A
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Efficacy of a diarylheptanoid derivative against Leishmania amazonensis [PDF]
Memórias do Instituto Oswaldo Cruz, 2003 The activity of several diarylheptanoid derivatives (curcuminoids) was previously evaluated against Leishmania amazonensis promastigotes and among them the most active compound was the [1-(4-methoxy-phenyl)-7-(3,4-methoxy-4-hydroxy-phenyl)-1,6-heptadien-3, 5-dione]. This derivative was chosen to be assayed in vivo in a treatment trial.
Luciana Vignólio Alves +3 more
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Characterization of an extracellular serine protease ofLeishmania (Leishmania) amazonensis
Parasitology, 2005 A serine protease was purified 942-fold from culture supernatant ofL. amazonensispromastigotes using (NH4)2SO4precipitation followed by affinity chromatography on aprotinin-agarose and continuous elution electrophoresis by Prep Cell, yielding a total recovery of 61%.
R E, Silva-Lopez +2 more
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Leishmania amazonensis: Characterization of an ecto-phosphatase activity [PDF]
Experimental Parasitology, 2006 We have characterized a phosphatase activity present on the external surface of Leishmania amazonensis, using intact living parasites. This enzyme hydrolyzes the substrate p-nitrophenylphosphate (p-NPP) at the rate of 25.70+/-1.17 nmol Pi x h(-1) x 10(-7)cells. The dependence on p-NPP concentration shows a normal Michaelis-Menten kinetics for this ecto-
Elmo Eduardo, de Almeida-Amaral +3 more
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Cinnamides Target Leishmania amazonensis Arginase Selectively [PDF]
Molecules, 2020 Caffeic acid and related natural compounds were previously described as Leishmania amazonensis arginase (L-ARG) inhibitors, and against the whole parasite in vitro. In this study, we tested cinnamides that were previously synthesized to target human arginase.
Edson Roberto da Silva +10 more
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Memorias do Instituto Oswaldo Cruz, 1987 Inhibition of one Leishmania subspecies by exometabolites of another subspecies, a phenomenon not previously reported, is suggested by our recent observations in cell cloning experiments with Leishmania mexicana mexicana and Leishmania mexicana ...
Raquel S. Pacheco +2 more
doaj +1 more source
Desenvolvimento de um teste colorimétrico para triagem da atividade leishmanicida de compostos utilizando Leishmania amazonensis expressando a enzima beta-galactosidase [PDF]
, 2013 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-graduação em Biotecnologia e Biociências, Florianópolis, 2013No presente trabalho transfectamos uma cepa de Leishmania amazonensis com um plasmídeo contendo o gene da ...
Tonini, Maiko Luis
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