In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis
PLoS Neglected Tropical Diseases, 2012 Antitumor cyclopalladated complexes with low toxicity to laboratory animals have shown leishmanicidal effect. These findings stimulated us to test the leishmanicidal property of one palladacycle compound called DPPE 1.2 on Leishmania (Leishmania) amazonensis, an agent of simple and diffuse forms of cutaneous leishmaniasis in the Amazon region, Brazil ...
Carolina de Siqueira Paladi +6 more
openaire +4 more sources
Revista da Sociedade Brasileira de Medicina Tropical, 2008 Total antigen from Leishmania (Leishmania) amazonensis and isolates from the Leishmania braziliensis complex, along with their respective antigenic fractions obtained by affinity chromatography on concanavalin-A-Sepharose and jacalin-agarose columns ...
Adriano Gomes-Silva +8 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundLeishmaniasis is a neglected arthropod-borne disease that affects millions of people worldwide. Successful Leishmania infections require the mitigation of immune cell functions leading to parasite survival and proliferation.
Rafael Tiburcio +17 more
doaj +1 more source
Parasites & Vectors, 2017 Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia).
Marcello Ceccarelli +7 more
doaj +1 more source
The role of leishmania proteophosphoglycans in sand fly transmission and infection of the Mammalian host. [PDF]
, 2012 Leishmania are transmitted by the bite of their sand fly vector and this has a significant influence on the virulence of the resulting infection. From our studies into the interaction between parasite, vector, and host we have uncovered an important ...
Rogers, Matthew E +2 more
core +1 more source
MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]
, 2010 In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
McGachy, H.A. +9 more
core +4 more sources
Microorganisms, 2021 Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses.
Manuel Soto +6 more
doaj +1 more source
Infecção natural por Leishmania sp. em flebotomíneos capturados no foco de transmissão de Leishmaniose Tegumentar Americana no município de Piçarras, litoral norte do Estado de Santa Catarina e identificação específica do parasito em amostras clínicas e em cepas isoladas de pacientes. [PDF]
, 2008 TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.As Leishmanioses são doenças infecto-parasitárias causadas por protozoários do gênero Leishmania, que acometem cerca de 12 milhões de indivíduos em 88 países
Bittencourt, Ize de Aguiar
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Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis [PDF]
Natural Product Research, 2016 Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and Leishmania braziliensis. Additionally, a quantitative structure activity relationship has been made, since all these natural compounds were found to have potent to mild ...
A Sosa +7 more
openaire +3 more sources
Inhibition of pteridine reductase 1 (PTR1) expression in Leishmania promastigotes using a full-length antisense construct [PDF]
, 2009 Leishmania exhibit many unusual features, one of which is the pteridine metabolic pathway essential for the growth for these parasites. Leishmania have evolved a complex and versatile pteridine salvage network capable of scavenging a wide array of ...
Nariman Mosaffa +7 more
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