Results 71 to 80 of about 10,337 (219)

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis.

PLoS Neglected Tropical Diseases, 2019
BackgroundLeishmania parasites are transmitted to vertebrate hosts by phlebotomine sandflies and, in humans, may cause tegumentary or visceral leishmaniasis.
Carolina Torturella Rath, Laila Castro Schnellrath, Clarissa R Damaso, Luciana Barros de Arruda, Pedro Fernando da Costa Vasconcelos, Claudia Gomes, Marcia Dalastra Laurenti, Teresa Cristina Calegari Silva, Áislan de Carvalho Vivarini, Nicolas Fasel, Renata Meirelles Santos Pereira, Ulisses Gazos Lopes   +11 more
doaj   +1 more source

Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis [PDF]

Natural Product Research, 2016
Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and Leishmania braziliensis. Additionally, a quantitative structure activity relationship has been made, since all these natural compounds were found to have potent to mild ...
A Sosa, Susana Amaya, Efraín Salamanca, Miguel Gilabert, Alicia Bardón, Alberto Giménez, Nancy Vera, Susana Borkosky   +7 more
openaire   +3 more sources

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Leishmania mexicana in Proechimys iheringi denigratus Moojen (Rodentia, Echimyidae) in a region endemic for American cutaneous leishmaniasis

Revista da Sociedade Brasileira de Medicina Tropical, 1985
Three isolates of Leishmania were recovered from five of 27 specimens of the rodent Proechimys iheringi denigratus Moojen captured near Três Braços in the Atlantic Forest region of Bahia, Brazil.
Air C. Barretto, Norman E. Peterson, Ednaldo Lago, Ana C. Rosa, Rosely S.M. Braga, Cesar A.C. Cuba, Julio A. Vexenat, Philip D. Marsden   +7 more
doaj   +3 more sources

Hairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis

Experimental Parasitology, 2015
HRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control.
Araujo, Vanessa Carneiro Pereira, Fukutani, Kiyoshi Ferreira, Oshiro, Elisa Teruya, Rodrigues, Patrik Oening, Rizk, Yasmin Silva, Carollo, Carlos Alexandre, Arruda, Carla Cardozo Pinto   +6 more
openaire   +2 more sources

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Proteomic Analysis Reveals a Predominant NFE2L2 (NRF2) Signature in Canonical Pathway and Upstream Regulator Analysis of Leishmania-Infected Macrophages

Frontiers in Immunology, 2019
CBA mice macrophages (MØ) control infection by Leishmania major and are susceptive to Leishmania amazonensis, suggesting that both parasite species induce distinct responses that play important roles in infection outcome.
Juliana Perrone Bezerra de Menezes, Ricardo Khouri, Ricardo Khouri, Camila Victoria Sousa Oliveira, Antonio Luis de Oliveira Almeida Petersen, Tais Fontoura de Almeida, Tais Fontoura de Almeida, Flávia R. L. Mendes, Amanda do Amor Divino Rebouças, Amanda Lopes Lorentz, Nívea Farias Luz, Jonilson Berlink Lima, Pablo Ivan Pereira Ramos, Rodrigo Pedro Soares, Jeronimo Nunes Rugani, Gregory A. Buck, Marco Aurélio Krieger, Fabrício Klerynton Marchini, Áislan de Carvalho Vivarini, Ulisses Gazos Lopes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras, Patricia Sampaio Tavares Veras   +22 more
doaj   +1 more source

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis

Frontiers in Medicine, 2019
Leishmaniasis is a complex of neglected diseases caused by parasites of the genus Leishmania, such as Leishmania (Leishmania) amazonensis, the ethiologic agent of diffuse cutaneous leishmaniasis in Brazil. In this work, we investigated a new experimental
Júlio Souza dos-Santos, Luan Firmino-Cruz, Tadeu Diniz Ramos, Alessandra Marcia da Fonseca-Martins, Diogo Oliveira-Maciel, Juliana Valente Rodrigues De-Medeiros, Suzana Passos Chaves, Daniel Claudio Oliveira Gomes, Herbert Leonel de Matos Guedes, Herbert Leonel de Matos Guedes   +9 more
doaj   +1 more source