Results 1 to 10 of about 61,193 (214)

Natural infection of the opossum Didelphis albiventris (Marsupialia, Didelphidae) with Leishmania donovani, in Brazil [PDF]

Memorias do Instituto Oswaldo Cruz, 1984
An opossum, Didelphis albiventris, from Jacobina, bahia State, was found naturally infected with Leishmania donovani, being the first non-canid wild mammal to be detected with agent of kala-azar in the New World.Um gambá, Didelphis albiventris, de ...
Ítalo A. Sherlock, José Carlos Miranda, Moysés Sadigursky, Gabriel Grimaldi Júnior   +3 more
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Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani

Frontiers in Immunology, 2021
Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL diminish due to emerging drug resistance. Although the principal host cells for the multiplication of Leishmania are macrophages, neutrophils are the first ...
Mareike Ohms, Carolina Ferreira, Carolina Ferreira, Hauke Busch, Inken Wohlers, Ana Cristina Guerra de Souza, Ricardo Silvestre, Ricardo Silvestre, Tamás Laskay   +8 more
doaj   +2 more sources

HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani. [PDF]

PLoS ONE, 2017
Histone post-translational modifications (PTMs) such as acetylation and methylation are known to affect chromatin higher order structures. Primary targets of these modifications include basic residues present at N-terminus tail region of core histones ...
Pravin K Jha, Mohd Imran Khan, Anshul Mishra, Pradeep Das, Kislay K Sinha   +4 more
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Global genome diversity of the Leishmania donovani complex

eLife, 2020
Protozoan parasites of the Leishmania donovani complex – L. donovani and L. infantum – cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the ...
Susanne U Franssen, Caroline Durrant, Olivia Stark, Bettina Moser, Tim Downing, Hideo Imamura, Jean-Claude Dujardin, Mandy J Sanders, Isabel Mauricio, Michael A Miles, Lionel F Schnur, Charles L Jaffe, Abdelmajeed Nasereddin, Henk Schallig, Matthew Yeo, Tapan Bhattacharyya, Mohammad Z Alam, Matthew Berriman, Thierry Wirth, Gabriele Schönian, James A Cotton   +20 more
doaj   +2 more sources

Evaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka [PDF]

Parasitology
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion.
Hasna Riyal, Nilakshi Samaranayake, Priyani Amarathunga, Deepani Munidasa, Nadira Karunaweera   +4 more
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Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation [PDF]

Microbiology Spectrum, 2023
Polyclonal B cell activation and the resulting hypergammaglobulinemia are a detrimental consequence of visceral leishmaniasis (VL); however, the mechanisms underlying this excessive production of nonprotective antibodies are still poorly understood. Here,
Tanja Stögerer, Sasha Silva-Barrios, Liseth Carmona-Pérez, Sharada Swaminathan, Linh Thuy Mai, Louis-Philippe Leroux, Maritza Jaramillo, Albert Descoteaux, Simona Stäger   +8 more
doaj   +2 more sources

Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018

Emerging Infectious Diseases, 2020
We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical cutaneous disease caused by Leishmania donovani parasites. L. donovani variants causing cutaneous
Lovlesh Thakur, Kiran K. Singh, Hemant R. Kushwaha, Sudarshan K. Sharma, Vinay Shankar, Ajeet Negi, Ghanshyam Verma, Sandhya Kumari, Aklank Jain, Manju Jain   +9 more
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Emerging Leishmania donovani Lineages Associated with Cutaneous Leishmaniasis, Himachal Pradesh, India, 2023 [PDF]

Emerging Infectious Diseases
The clinical manifestation of leishmaniasis has historically been determined by the Leishmania species involved. However, recent emergence of novel Leishmania lineages has caused atypical pathologies.
Patrick Lypaczewski, Yogesh Chauhan, Kayla Paulini, Lovlesh Thakur, Shailja Chauhan, Ezrah Isaac Roy, Greg Matlashewski, Manju Jain   +7 more
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Genetic diversity of Leishmania donovani that causes cutaneous leishmaniasis in Sri Lanka: a cross sectional study with regional comparisons

BMC Infectious Diseases, 2017
Background Leishmania donovani is the etiological agent of visceral leishmaniasis (VL) in the Indian subcontinent. However, it is also known to cause cutaneous leishmaniasis (CL) in Sri Lanka. Sri Lankan L. donovani differs from other L. donovani strains,
Udeshika Lakmini Kariyawasam, Angamuthu Selvapandiyan, Keshav Rai, Tasaduq Hussain Wani, Kavita Ahuja, Mizra Adil Beg, Hasitha Upendra Premathilake, Narayan Raj Bhattarai, Yamuna Deepani Siriwardena, Daibin Zhong, Guofa Zhou, Suman Rijal, Hira Nakhasi, Nadira D. Karunaweera   +13 more
doaj   +2 more sources

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

mBio, 2015
The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms.
Wen-Wei Zhang, Greg Matlashewski
doaj   +2 more sources