Multifaceted population structure and reproductive strategy in Leishmania donovani complex in one Sudanese village. [PDF]
PLoS Neglected Tropical Diseases, 2011 Leishmania species of the subgenus Leishmania and especially L. donovani are responsible for a large proportion of visceral leishmaniasis cases. The debate on the mode of reproduction and population structure of Leishmania parasites remains opened.
Virginie Rougeron +8 more
doaj +1 more source
HAT2 mediates histone H4K4 acetylation and affects micrococcal nuclease sensitivity of chromatin in Leishmania donovani. [PDF]
PLoS ONE, 2017 Histone post-translational modifications (PTMs) such as acetylation and methylation are known to affect chromatin higher order structures. Primary targets of these modifications include basic residues present at N-terminus tail region of core histones ...
Pravin K Jha +4 more
doaj +1 more source
LEISHMANIA DONOVANI IN THE PERIPHERAL BLOOD [PDF]
Journal of Experimental Medicine, 1923 1. The effect of human red cells and serum on the growth of Leishmania donovani has been studied and a blood culture method devised, based on these findings. 2. The distribution of blood platelets and of the different varieties of leucocytes in the strata of centrifugalized diluted blood has been investigated, and also the distribution ...
C W, Young, H M, Van Sant
openaire +2 more sources
Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]
, 2020 A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia +5 more
core +1 more source
Vaccine Development Against Leishmania donovani [PDF]
Frontiers in Immunology, 2012 La leishmaniasis visceral (VL) causada por Leishmania donovani y Leishmania infantum/chagasi representa la segunda enfermedad infecciosa más difícil en todo el mundo, lo que lleva a casi 500.000 nuevos casos y 60.000 muertes al año. La VL zoonótica causada por L.
Amrita Das, Nahid Ali
openaire +3 more sources
Comprehensive proteomic analysis of autophagosomes derived from Leishmania-infected macrophages.
PLoS ONE, 2023 Recently, autophagy has been implicated as a host defense mechanism against intracellular pathogens. On the other hand, certain intracellular pathogens such as Leishmania can manipulate the host's autophagy to promote their survival.
Devki Nandan +5 more
doaj +1 more source
Microbiology Spectrum, 2022 Infection with Leishmania donovani reduces cellular cholesterol and thus deprives the host cells by inhibiting its synthesis and uptake. Changes in cholesterol levels increase the chance of attachment and internalization of L. donovani in macrophages (Mϕ)
Satya Prakash, Ambak Kumar Rai
doaj +1 more source
In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]
, 2014 Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core +2 more sources
Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]
, 2016 Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E +19 more
core +3 more sources