Results 31 to 40 of about 1,239 (69)

New insights into Sti1/Hop's cochaperone function highlight the complexity of proteostatic regulation

The FEBS Journal, EarlyView.
Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch, Adrienne Lesley Edkins   +1 more
wiley   +1 more source

Exploring Aspartate Transcarbamoylase: A Promising Broad‐Spectrum Target for Drug Development

ChemBioChem, Volume 26, Issue 7, April 1, 2025.
Pyrimidine biosynthesis is a pivotal process shared by both eukaryotes and prokaryotes. This review examines the applications and advantages of a series of inhibitors specifically designed to target aspartate transcarbamylase within the de novo biosynthetic pathway of the malarial parasite.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Carsten Wrenger, Alexander S. S. Dömling, Özlem Tastan Bishop, Matthew R. Groves   +8 more
wiley   +1 more source

Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2014
BackgroundVisceral leishmaniasis (VL), a widely distributed systemic disease caused by infection with the Leishmania donovani complex (L. donovani and L. infantum), is almost always fatal if symptomatic and untreated.
Tapan Bhattacharyya, Duncan E Bowes, Sayda El-Safi, Shyam Sundar, Andrew K Falconar, Om Prakash Singh, Rajiv Kumar, Osman Ahmed, Marleen Boelaert, Michael A Miles   +9 more
doaj   +1 more source

Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani. [PDF]

PLoS ONE, 2015
The early stage of Leishmania development in sand flies is closely connected with bloodmeal digestion. Here we compared various parameters of bloodmeal digestion in sand flies that are either susceptible (Phlebotomus argentipes and P.
Katerina Pruzinova, Jovana Sadlova, Veronika Seblova, Miroslav Homola, Jan Votypka, Petr Volf   +5 more
doaj   +1 more source

From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection

The FEBS Journal, Volume 292, Issue 8, Page 1868-1883, April 2025.
Traditionally, adipocytes have been viewed as energy storage units, which upregulate inflammatory factors in response to obesity. However, emerging evidence demonstrates that adipocytes are highly responsive to systemic infection, and upregulate cytokines and antimicrobial compounds in response.
Matthew C. Sinton, Shingo Kajimura
wiley   +1 more source

Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia

Cell Reports, 2016
Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios, Mélina Smans, Claudia U. Duerr, Salman T. Qureshi, Jörg H. Fritz, Albert Descoteaux, Simona Stäger   +6 more
doaj   +1 more source

Intestinal mucosal immunity and type 1 diabetes: Non‐negligible communication between gut and pancreas

Diabetes, Obesity and Metabolism, Volume 27, Issue 3, Page 1045-1064, March 2025.
Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by T cell‐mediated pancreatic β cell loss, resulting in lifelong absolute insulin deficiency and hyperglycaemia. Environmental factors are recognized as a key contributor to the development of T1D, with the gut serving as a primary interface for environmental stimuli.
Ruonan Liu, Jing Zhang, Si Chen, Yang Xiao, Jingyi Hu, Zhiguang Zhou, Lingxiang Xie   +6 more
wiley   +1 more source

Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.

PLoS Neglected Tropical Diseases, 2020
BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira, Inês Mesquita, Ana Margarida Barbosa, Nuno Sampaio Osório, Egídio Torrado, Charles-Joly Beauparlant, Arnaud Droit, Cristina Cunha, Agostinho Carvalho, Bhaskar Saha, Jerôme Estaquier, Ricardo Silvestre   +11 more
doaj   +1 more source

Fungal Biomolecules for Food and Pharmaceutical Application

eFood, Volume 6, Issue 1, February 2025.
The review summarizes the diverse roles of fungal biomolecules in the food and pharmaceutical industries and highlights their significant contribution to modern medicine and health‐related fields. ABSTRACT Mushrooms have long been an integral part of human culture and health and are valued for their nutritional and therapeutic properties.
Giancarlo Angeles Flores, Gaia Cusumano, Gokhan Zengin, Roberto Venanzoni, Paola Angelini   +4 more
wiley   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source