Results 41 to 50 of about 1,239 (69)

The effect of Marigold flower extracts on growth of Leishmania. [PDF]

Kirkuk Journal of Science, 2018
This study searched in the inhibiting potency of different concentrations (12.5, 25, 50 and 100 µg/mL) of both aqueous and methanol extracts of marigold plant flower Calendula officinalis against the promastigote of Leismania major, L. donovani and
Neama Ali Ahmad
doaj   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

First Molecular Characterization of Leishmania Species Causing Visceral Leishmaniasis among Children in Yemen.

PLoS ONE, 2016
Visceral leishmaniasis (VL) is a debilitating, often fatal disease caused by Leishmania donovani complex; however, it is a neglected tropical disease. L. donovani complex comprises two closely related species, L. donovani that is mostly anthroponotic and
Mohammed A K Mahdy, Abdulsalam M Al-Mekhlafi, Rashad Abdul-Ghani, Reyadh Saif-Ali, Hesham M Al-Mekhlafi, Samira M Al-Eryani, Yvonne A L Lim, Rohela Mahmud   +7 more
doaj   +1 more source

Sphingosine-1-phosphate signaling in Leishmania donovani infection in macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2018
BACKGROUND:Sphingosine-1-phosphate (S1P) is a crucial regulator of a wide array of cellular processes, such as apoptosis, cell proliferation, migration, and differentiation, but its role in Leishmania donovani infection is unknown. METHODOLOGY/ PRINCIPAL
Mohd Arish, Atahar Husein, Rahat Ali, Shams Tabrez, Farha Naz, Mohammad Zulfazal Ahmad, Abdur Rub   +6 more
doaj   +1 more source

The carbonic anhydrase enzymes as new targets for the management of neglected tropical diseases

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
The scientific literature dealing with the identification and development of selective inhibitors of the carbonic anhydrases expressed by the protozoans Trypanosoma cruzi (T. cruzi) and Leishmania spp. is reviewed and analyzed, with the aim to sustain the validation process of new classes of drugs useful for the management of neglected tropical ...
Gioele Renzi, Federico Ladu, Fabrizio Carta, Claudiu T. Supuran   +3 more
wiley   +1 more source

Global genome diversity of the Leishmania donovani complex

eLife, 2020
Protozoan parasites of the Leishmania donovani complex – L. donovani and L. infantum – cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most of the ...
Susanne U Franssen, Caroline Durrant, Olivia Stark, Bettina Moser, Tim Downing, Hideo Imamura, Jean-Claude Dujardin, Mandy J Sanders, Isabel Mauricio, Michael A Miles, Lionel F Schnur, Charles L Jaffe, Abdelmajeed Nasereddin, Henk Schallig, Matthew Yeo, Tapan Bhattacharyya, Mohammad Z Alam, Matthew Berriman, Thierry Wirth, Gabriele Schönian, James A Cotton   +20 more
doaj   +1 more source

Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine‐1,1‐dioxide

Chemistry &Biodiversity, Volume 22, Issue 1, January 2025.
Abstract Leishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease.
Nadine Henning, Christina Kannigadu, Janine Aucamp, Helena D. Janse van Rensburg, Frank van der Kooy, David D. N'Da   +5 more
wiley   +1 more source

Structure of Plasmodium vivaxN‐myristoyltransferase with inhibitor IMP‐1088: exploring an NMT inhibitor for antimalarial therapy

Acta Crystallographica Section F, Volume 81, Issue 1, Page 1-10, January 2025.
The 1.8 Å resolution ternary structure of P. vivaxN‐myristoyltransferase in complex with IMP‐1088 and myristoyl‐CoA is presented. IMP‐1088 is an N‐myristoyltransferase inhibitor from a family of inhibitors that are under investigation as antimalarials.Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating health burden
Alex Mendez, Cydni Bolling, Shane Taylor, Stanley Makumire, Bart Staker, Alexandra Reers, Brad Hammerson, Stephen J. Mayclin, Jan Abendroth, Donald D. Lorimer, Thomas E. Edwards, Edward W. Tate, Sandhya Subramanian, Andrew S. Bell, Peter J. Myler, Oluwatoyin A. Asojo, Graham Chakafana   +16 more
wiley   +1 more source

Identification of potential inhibitor against Leishmania donovani mitochondrial DNA primase through in-silico and in vitro drug repurposing approaches

Scientific Reports
Leishmania donovani is the causal organism of leishmaniasis with critical health implications affecting about 12 million people around the globe. Due to less efficacy, adverse side effects, and resistance, the available therapeutic molecules fail to ...
Mitul Nath, Deep Bhowmik, Satabdi Saha, Rajat Nandi, Diwakar Kumar   +4 more
doaj   +1 more source

Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

Brazilian Journal of Medical and Biological Research, 2006
Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species.
P.R.T. Romão, J. Tovar, S.G. Fonseca, R.H. Moraes, A.K. Cruz, J.S. Hothersall, A.A. Noronha-Dutra, S.H. Ferreira, F.Q. Cunha   +8 more
doaj   +1 more source