Results 51 to 60 of about 1,239 (69)

Performance of Extracellular Vesicles From Leishmania (Leishmania) infantum for Serological Diagnosis of Human and Canine Visceral Leishmaniasis

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
Allecineia Bispo da Cruz, Francieli Marinho Carneiro, Noemi Nosomi Taniwaki, Gislene Mitsue Namiyama, Débora Oliveira dos Santos, Katia Gomes Castellão, Isabelle Martins Ribeiro Ferreira, Roberto Mitsuyoshi Hiramoto, Vera Lucia Pereira-Chioccola, Bernard Marchand   +9 more
wiley   +1 more source

Evaluation of CD1a immunostaining in the diagnosis of cutaneous leishmaniasis caused by Leishmania donovani in Sri Lanka

Parasitology
Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease, routinely diagnosed by direct light microscopy. The sensitivity of this method is dependent on the number of parasites present in the lesion.
Hasna Riyal, Nilakshi Samaranayake, Priyani Amarathunga, Deepani Munidasa, Nadira Karunaweera   +4 more
doaj   +1 more source

Miransertib (ARQ 092), an orally-available, selective Akt inhibitor is effective against Leishmania. [PDF]

PLoS ONE, 2018
Leishmaniasis is amongst the most important neglected diseases, afflicting more than 12 million people in 88 countries. There is an urgent need for safe orally bioavailable and cost-effective drugs for the treatment of leishmaniasis. It has recently been
Devki Nandan, Naixin Zhang, Yi Yu, Brian Schwartz, Stella Chen, Peter E Kima, Neil E Reiner   +6 more
doaj   +1 more source

Acanthamoeba castellanii–Mediated Reduction of Interleukin‐1β Secretion and Its Association With Macrophage Autophagy

Scientifica, Volume 2025, Issue 1, 2025.
Noncanonical autophagy including unconventional protein secretion has been extensively studied. Our work focused on a leaderless IL‐1β protein secretion from human macrophage in response to Acanthamoeba castellanii components, Acanthamoeba culture supernatant (CS) and cell lysate (CL), as well as its association with macrophage autophagy.
Rachasak Boonhok, Wilaiwan Senghoi, Suthinee Sangkanu, Chooi Ling Lim, Matsayapan Pudla, Maria de Lourdes Pereira, Polrat Wilairatana, Tooba Mahboob, Md. Atiar Rahman, Pongsak Utaisincharoen, Poonsit Hiransai, Veeranoot Nissapatorn, Simone Carradori   +12 more
wiley   +1 more source

Amebicidal and Antiadhesion Activities of Knema retusa Extract Against Acanthamoeba triangularis T4 Genotype on Contact Lenses and Modeling Simulation of Its Main Compound, E2N, Against Acanthamoeba Beta‐Tubulin

Scientifica, Volume 2025, Issue 1, 2025.
Medicinal plants have been used as alternative agents for the treatment of infections. This study aimed to investigate bioactivities of medicinal plant extracts including Knema retusa extract (Kre) against Acanthamoeba triangularis T4 in vitro and in silico. Anti‐Acanthamoeba activities of 44 extracts from 5 plant species were determined.
Watcharapong Mitsuwan, Imran Sama-ae, Suthinee Sangkanu, Dhrubo Ahmed Khan, Partha Biswas, Md. Nazmul Hasan, Julalak Chuprom, Tajudeen O. Jimoh, Christophe Wiart, Masyitah Binti Zulkipli, Nor Hayati Abdullah, Maria de Lourdes Pereira, Sonia M. Rodrigues Oliveira, Shanmuga Sundar Saravanabhavan, Polrat Wilairatana, Tooba Mahboob, Veeranoot Nissapatorn, Sukhamoy Gorai   +17 more
wiley   +1 more source

Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms (Diplocystidiaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 21, Issue 12, December 2024.
Abstract Edible Astraeus mushrooms are known for their nutritional and culinary benefits and potential therapeutic properties. However, more investigation and discussion are still needed to understand their mechanisms of action regarding observed biological activities and thorough chemical analysis of bioactive compounds.
Alison T. Ung, Hui Chen
wiley   +1 more source

L-Asparaginase of Leishmania donovani: Metabolic target and its role in Amphotericin B resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Emergence of Amphotericin B (AmB) resistant Leishmania donovani has posed major therapeutic challenge against the parasite. Consequently, combination therapy aimed at multiple molecular targets, based on proteome wise network analysis has been ...
Jasdeep Singh, Mohd Imran Khan, Shiv Pratap Singh Yadav, Ankit Srivastava, Kislay K. Sinha, Ashish, Pradeep Das, Bishwajit Kundu   +7 more
doaj  

Ecological determinants of leishmaniasis vector, Lutzomyia spp.: A scoping review

Medical and Veterinary Entomology, Volume 38, Issue 4, Page 393-406, December 2024.
Lutzomyia spp. survival is impacted by climatic, habitat and geodemographic factors. Lutzomyia spp. have demonstrated a wide range of temperature tolerance, ranging from 11 to 30°C. There is limited research on this topic, posing a significant challenge for future studies. Abstract Leishmania spp. are zoonotic parasites transmitted by phlebotomine sand
Sydney DeWinter, Keana Shahin, Christopher Fernandez‐Prada, Amy L. Greer, J. Scott Weese, Katie M. Clow   +5 more
wiley   +1 more source

Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018

Emerging Infectious Diseases, 2020
We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical cutaneous disease caused by Leishmania donovani parasites. L. donovani variants causing cutaneous
Lovlesh Thakur, Kiran K. Singh, Hemant R. Kushwaha, Sudarshan K. Sharma, Vinay Shankar, Ajeet Negi, Ghanshyam Verma, Sandhya Kumari, Aklank Jain, Manju Jain   +9 more
doaj   +1 more source

A cross‐sectional study on phlebotomine sand flies in relation to disease transmission in the Republic of Kosovo

Medical and Veterinary Entomology, Volume 38, Issue 4, Page 573-585, December 2024.
We provide the currently known sand fly distribution and species diversity in Kosovo, including a COI barcode inventory and distribution maps. Phlebotomus neglectus and Ph. perfiliewi were identified to be the predominant species and environmental analyses depicted two geographical groups of sand flies in Kosovo, with notable differences between the ...
Betim Xhekaj, Ina Hoxha, Katharina Platzgummer, Jovana Stefanovska, Vít Dvořák, Markus Milchram, Adelheid G. Obwaller, Wolfgang Poeppl, Nesade Muja‐Bajraktari, Julia Walochnik, Attila J. Trájer, Kurtesh Sherifi, Aleksandar Cvetkovikj, Edwin Kniha   +13 more
wiley   +1 more source