Results 51 to 60 of about 80,278 (299)

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

ACS Infectious Diseases, 2018
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L. infantum, is responsible for ∼30 000 deaths annually. Available treatments are inadequate, and there is a pressing need for new therapeutics. N-Myristoyltransferase
Victoriano Corpas-Lopez, S. Moniz, Michael G. Thomas, Richard J. Wall, L. S. Torrie, Dorothea Zander-Dinse, M. Tinti, S. Brand, L. Stojanovski, Sujatha Manthri, I. Hallyburton, F. Zuccotto, P. Wyatt, M. De Rycker, D. Horn, M. Ferguson, J. Clos, K. Read, A. Fairlamb, I. Gilbert, S. Wyllie   +20 more
semanticscholar   +1 more source

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources

Identification of Leishmania donovani in blood of experimentally infected rats by quantitative real-time PCR

Al-Qadisiyah Journal of Veterinary Medicine Sciences, 2018
The present study has been carried out at the Department of Microbiology and Parasitology, College of Veterinary Medicine/Al-Qadisiyah University to diagnose the visceral leishmaniasis molecular technique (Quantitative real-time polymerase chain reaction)
Noor Idan Jarad, Ghaidaa Abbas Jasim
doaj   +1 more source

Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting

mBio, 2020
Interferon (IFN)-inducible guanylate binding proteins (GBPs) play important roles in host defense against many intracellular pathogens that reside within pathogen-containing vacuoles (PVs).
Arun Kumar Haldar, Utsav Nigam, Masahiro Yamamoto, Jörn Coers, Neena Goyal   +4 more
doaj   +1 more source

Characterisation of the Leishmania donovani/L. infantum Hybrid Isolated from an Autochothonous Kala-Azar Patient: Preliminary Results of an In Vivo Model

Türkiye Parazitoloji Dergisi, 2021
Objective:In the present study, preliminary outcomes of the in vivo assessment of a Leishmania donovani/L. infantum hybrid isolated from a hospitalised patient with visceral leishmaniasis in Manisa and identified through analysis of the Leishmania ...
Özgür Kurt, Nesteren Mansur Özen, Elif Merve Aydın, Deniz Ece Kaya, Cavit Kerem Kayhan, Sinem Öktem Okullu, Ümit İnce, Fadile Yıldız Zeyrek   +7 more
doaj   +1 more source

Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent

Msphere, 2018
The “antibiotic resistance crisis” is a major challenge for scientists and medical professionals. This steady rise in drug-resistant pathogens also extends to parasitic diseases, with antimony being the first anti-Leishmania drug that fell in the Indian ...
F. Dumetz, Bart Cuypers, Bart Cuypers, H. Imamura, Dorothea Zander, Erika D’haenens, I. Maes, M. Domagalska, J. Clos, J. Dujardin, J. Dujardin, G. Muylder   +11 more
semanticscholar   +1 more source

Development of a LAMP assay for detection of Leishmania infantum infection in dogs using conjunctival swab samples [PDF]

, 2015
Background: Leishmania infantum infections in dogs play a crucial role in the transmission of pathogens causing visceral leishmaniasis to humans in the Gansu province, northwest China. To be able to control zoonotic transmission of the parasite to humans,
A Moshfe, A Nasereddin, AF Koutinas, CH Gao, Chun-hua Gao, D Otranto, D Strauss-Ayali, Dan Ding, Dietmar Steverding, ER Adams, F Dantas-Torres, Feng Shi, G Schönian, H Kaneko, H Takagi, J Alvar, J Dereure, JM Lawrie, Jun-yun Wang, JY Wang, JY Wang, JY Wang, K Stuart, L Chamaillé, L He, L Solano-Gallego, LL Poon, LS Leontides, M Chaouch, M Gramiccia, M Paiva Cavalcanti de, MG Khan, N Chargui, N Kuboki, N Singh, P Ciaramella, RS Leite, S Reale, SA Ferreira, T Muccio Di, T Notomi, UG Lopes, WP Kennedy, X Ni, Xia Wang, Y Fichoux le, Y Mori, YM Gomes, Yue-tao Yang   +48 more
core   +1 more source

Identification of internalin-A-like virulent proteins in Leishmania donovani

Parasites & Vectors, 2016
Background An active immune surveillance and a range of barriers to infection allow the host to effectively eliminate microbial pathogens. However, pathogens may use diverse strategies to subdue such host defences. For instance, one such mechanism is the
Ishita Mukherjee, Abhijit Chakraborty, Saikat Chakrabarti   +2 more
doaj   +1 more source

Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani

PLoS Neglected Tropical Diseases, 2019
Bacterial strains isolated from attine ants showed activity against the insect specialized fungal pathogen Escovopsis and also against the human protozoan parasite Leishmania donovani.
Humberto E. Ortega, L. Ferreira, Weilan G. P. Melo, Ana Ligia L Oliveira, René F Ramos Alvarenga, N. Lopes, T. Bugni, A. Andricopulo, M. Pupo   +8 more
semanticscholar   +1 more source

Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani

Nature Ecology & Evolution, 2017
The parasite Leishmania donovani causes a fatal disease termed visceral leishmaniasis. The process through which the parasite adapts to environmental change remains largely unknown.
Pablo Prieto Barja, P. Pescher, G. Bussotti, F. Dumetz, H. Imamura, D. Kedra, M. Domagalska, Victor Chaumeau, H. Himmelbauer, M. Pagès, Y. Sterkers, J. Dujardin, Cédric Notredame, G. Späth   +13 more
semanticscholar   +1 more source