Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani. [PDF]
PLoS ONE, 2015 The early stage of Leishmania development in sand flies is closely connected with bloodmeal digestion. Here we compared various parameters of bloodmeal digestion in sand flies that are either susceptible (Phlebotomus argentipes and P.
Katerina Pruzinova +5 more
doaj +1 more source
A Killing Disease Epidemic Among Displaced Sudanese Population Identified as Visceral Leishmaniasis. [PDF]
, 1991 A fatal disease epidemic affected the Bentiu area in southern Sudan and led to a mass migration of the Nuer tribe searching for treatment. The initially available information revealed a high mortality rate due to a possible occurrence of tuberculosis ...
Chantal, B +5 more
core +2 more sources
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
ChemMedChem, EarlyView.Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi +7 more
wiley +1 more source
CRISPR-Cas9-Mediated Genome Editing in
mBio, 2015 The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms.
Wen-Wei Zhang, Greg Matlashewski
doaj +1 more source
Application of kDNA as a molecular marker to analyse Leishmania infantum diversity in Portugal.
, 2006 Around the Mediterranean basin Leishmania infantum is an important parasite causing canine leishmaniasis and visceral and cutaneous clinical forms in both immunocompetent and immunocompromised humans.
Almeida, Ana +6 more
core +1 more source
Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire
PROTEOMICS, EarlyView.ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley +1 more source
Adenine and adenosine salvage in Leishmania donovani [PDF]
Molecular and Biochemical Parasitology, 2013 6-aminopurine metabolism in Leishmania is unique among trypanosomatid pathogens since this genus expresses two distinct routes for adenine salvage: adenine phosphoribosyltransferase (APRT) and adenine deaminase (AAH). To evaluate the relative contributions of APRT and AAH, adenine salvage was evaluated in Δaprt, Δaah, and Δaprt/Δaah null mutants of L ...
Buddy Ullman, Jan M. Boitz
openaire +3 more sources
Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.
PLoS Neglected Tropical Diseases, 2020 BackgroundThe disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection.
Carolina Ferreira +11 more
doaj +1 more source
Journal of Microscopy, EarlyView.Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson +2 more
wiley +1 more source
Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. [PDF]
PLoS ONE, 2009 BACKGROUND:Glyoxalase I is a metalloenzyme of the glyoxalase pathway that plays a central role in eliminating the toxic metabolite methyglyoxal. The protozoan parasite Leishmania donovani possesses a unique trypanothione dependent glyoxalase system ...
Swati C Chauhan, Rentala Madhubala
doaj +1 more source