Results 141 to 150 of about 13,685 (176)

Assessing the composition of the plasma membrane of Leishmania (Leishmania) infantum and L. (L.) amazonensis using label-free proteomics

Experimental Parasitology, 2020
Protozoan parasites of the genus Leishmania are causative agents of leishmaniasis, a wide range of diseases affecting 12 million people worldwide. The species L. infantum and L. amazonensis are etiologic agents of visceral and cutaneous leishmaniasis, respectively.
Ivana H R, Oliveira, Henrique C P, Figueiredo, Cristiana P, Rezende, Thiago, Verano-Braga, Marcella N, Melo-Braga, João Luis, Reis Cunha, Hélida M, de Andrade   +6 more
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Assessing nystatin cream treatment efficacy against Leishmania (L.) amazonensis infection in BALB/c model

Experimental Parasitology, 2023
The current scenario for cutaneous leishmaniasis treatment includes the use of first and second-choice drugs, both therapeutic strategies presenting several adverse effects and being related to an increment of treatment-refractory parasite strains. These facts encourage the search for new treatment approaches, including repositioning drugs, such as ...
Luiz Filipe Gonçalves-Oliveira, Juliana Figueiredo Peixoto, Geovane Dias-Lopes, Franklin Souza-Silva, Luzia Monteiro de Castro Côrtes, Helvécio Vinícius Antunes Rocha, Carlos Roberto Alves   +6 more
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Pravastatin modulates macrophage functions of Leishmania (L.) amazonensis-infected BALB/c mice

Experimental Parasitology, 2013
The control of leishmaniases poses an important challenge due to the scarcity and toxicity of the pharmacological options available. We have previously shown that pravastatin significantly improves the course of the disease in Leishmania (L.) amazonensis-infected BALB/c mice.
Carlos S, Kückelhaus, Selma A S, Kückelhaus, Carlos Eduardo, Tosta, Maria Imaculada, Muniz-Junqueira   +3 more
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Inhibition of mouse lymphocyte proliferative response by glycosphingolipids from Leishmania (L.) amazonensis

Experimental Parasitology, 1992
The effect of a purified preparation of glycosphingolipids (GSLs) extracted from Leishmania (L.) amazonensis amastigotes on murine lymphocytes was investigated. GSLs inhibited both concanavalin A (Con A)- or lipopolysaccharide-induced [3H]thymidine uptake by normal and immunized BALB/c mouse lymph node cells. The effect of total GSLs was dose dependent.
S, Giorgio, M G, Jasiulionis, A H, Straus, H K, Takahashi, C L, Barbiéri   +4 more
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ExperimentalLeishmania (L.) amazonensisLeishmaniasis: Characterization and Immunogenicity of Subcellular Fractions

Immunological Investigations, 2007
A technique developed in Trypanosoma cruzi biochemical studies was successfully used to fractionate Leishmania (Leishmania) amazonensis promastigotes. Ultrastructural analyses revealed a membrane fraction (MF) associated to subpellicular microtubules, a ribosomal-rich microsomal fraction (MicF), and a flagellar fraction (FF) free of associated membrane.
T Zaverucha, do Valle, E B, Gaspar, C, Souza-Lemos, C S F, Souza, F B Zamora, Márquez, W, Baetas-da-Cruz, L N, d'Escofier, S, Côrte-Real, K S, Calabrese, S C Gonçalves, da Costa   +9 more
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Trypanosoma cruzi P21 protein exacerbates Leishmania (L.) amazonensis infection

Experimental Parasitology
The protozoan parasite Trypanosoma cruzi, the etiological agent of Chagas disease, affects millions of people worldwide. Current treatments rely on drugs effective only in the acute phase, making the search for new therapeutic targets a priority. While a recombinant protein based on T.
Thaise Lara, Teixeira, Samuel Cota, Teixeira, Bruna Cristina, Borges, João Paulo Silva, Servato, Elida Cristina Monteiro de, Oliveira, Teresiama, Velikkakam, Claudio Vieira da, Silva   +6 more
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Altered transport properties of pentamidine-resistant Leishmania donovani and L. amazonensis promastigotes

Parasitology Research, 1997
Pentamidine-resistant clones of Leishmania donovani and L. amazonensis promastigotes were developed by increase of the drug pressure in the culture medium and characterized. The resistant clones could grow in 40 and 20 microM pentamidine as determined for L. donovani and L.
M, Basselin, F, Lawrence, M, Robert-Gero
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Antileishmanial activity of a naphthoquinone derivate against promastigote and amastigote stages of Leishmania infantum and Leishmania amazonensis and its mechanism of action against L. amazonensis species

Parasitology Research, 2017
Leishmaniasis has become a significant public health issue in several countries in the world. New products have been identified to treat against the disease; however, toxicity and/or high cost is a limitation. The present work evaluated the antileishmanial activity of a new naphthoquinone derivate, Flau-A [2-(2,3,4-tri-O-acetyl-6-deoxy-β-L ...
Débora Vasconcelos Costa Mendonça, Daniela Pagliara Lage, Stephane Lima Calixto, Flaviano Melo Ottoni, Grasiele de Sousa Vieira Tavares, Fernanda Ludolf, Miguel Angel Chávez-Fumagalli, Mônica Santos Schneider, Mariana Costa Duarte, Carlos Alberto Pereira Tavares, Ricardo José Alves, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho   +12 more
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Morphological alterations and growth inhibition of Leishmania (L.)amazonensis promastigotes exposed to zidovudine (AZT)

Parasitology Research, 2010
Leishmania parasites cause a worldwide public health disease and its treatment is still based on pentavalent antimonials which present financial and toxicologic limitations. Some nucleosidic derivatives have demonstrated anti-leishmanial properties and this study aims to evaluate the in vitro morphologic alterations and growth inhibition of Leishmania (
Carolina A, Araújo, Aline A, Araújo, Camilla L, Batista, Milton A P, Oliveira, Valeria, Oliveira, Ruy S, Lino Junior, Marina C, Vinaud, Jose C B, Bezerra   +7 more
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Lantana camara L. induces a multi-targeted cell death process in Leishmania amazonensis

Journal of Ethnopharmacology
Lantana camara L. is a species known for its broad spectrum of bioactivities and is commonly used in folk therapy to address inflammatory, dermatological, gastrointestinal, intestinal worms and protozoan diseases. It boasts a diverse array of secondary metabolites such as terpenes, flavonoids, and saponins.
Ari Sérgio de Oliveira Lemos, Juliana da Trindade Granato, Luciana Maria Ribeiro Antinarelli, Patrícia de Almeida Machado, Lara Melo Campos, João Pedro Reis Costa Bastos, Victor do Valle Midlej, Adolfo Firmino da Silva Neto, Rodrigo Luiz Fabri, Elaine Soares Coimbra   +9 more
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