New delivery systems for amphotericin B applied to the improvement of leishmaniasis treatment [PDF]
, 2016 © 2015, Sociedade Brasileira de Medicina Tropical. All rights reserved. Leishmaniasis is one of the six major tropical diseases targeted by the World Health Organization.
Chávez-Fumagalli, Miguel A. +2 more
core +1 more source
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
Cell-to-cell transfer of Leishmania amazonensis amastigotes is mediated by immunomodulatory LAMP-rich parasitophorous extrusions [PDF]
, 2014 The last step of Leishmania intracellular life cycle is the egress of amastigotes from the host cell and their uptake by adjacent cells. Using multidimensional live imaging of long-term-infected macrophage cultures we observed that Leishmania amazonensis
Goto, Hiro +6 more
core +3 more sources
Insights on adaptive and innate immunity in canine leishmaniosis [PDF]
, 2016 Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah +19 more
core +4 more sources
Leishmania amazonensis promastigotes present two distinct modes of nucleus and kinetoplast segregation during cell cycle. [PDF]
, 2015 : Here, we show the morphological events associated with organelle segregation and their timing in the cell cycle of a reference strain of Leishmania (L.) amazonensis promastigotes, the main causative agent of Tegumentary leishmaniasis in the Americas ...
Cano, Maria Isabel Nogueira +7 more
core +2 more sources
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. [PDF]
, 2016 We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice.
Brombacher, F. +4 more
core +1 more source
PLOS Neglected Tropical Diseases, 2017 Leishmania uses the amino acid L-arginine as a substrate for arginase, enzyme that produces urea and ornithine, last precursor of polyamine pathway. This pathway is used by the parasite to replicate and it is essential to establish the infection in the mammalian host. L-arginine is not synthesized by the parasite, so its uptake occurs through the amino
Juliana Ide Aoki +7 more
openaire +4 more sources
Cytokine, 2017 In previous results mice treated with high dilutions of antimony presented reduction of monocyte migration to the site of infection with increase in B lymphocytes population in the local lymph node.To know the mechanisms involved, a series of in vitro studies was done, using co-cultures of macrophages (RAW 264.7) and Leishmania (L.) amazonensis treated
Fabiana Rodrigues, de Santana +14 more
openaire +2 more sources
Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. [PDF]
, 2010 A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania ...
Depledge, DP +7 more
core
Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids [PDF]
, 2017 The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp.
Damasceno, Jeziel D. +3 more
core +1 more source