Results 131 to 140 of about 5,616,372 (322)

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source

Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major

PLoS Neglected Tropical Diseases, 2015
Trypanosomatid parasites of the genus Leishmania are the causative agents of leishmaniasis, a neglected tropical disease with several clinical manifestations.
Kimbra G. Turner, P. Vacchina, Maricela Robles-Murguia, Mariha Wadsworth, M. McDowell, M. Morales   +5 more
semanticscholar   +1 more source

An Atypical Presentation of Disseminated Mucocutaneous Leishmaniasis Caused by Leishmania major In Iran

Iranian Journal of Parasitology, 2018
Although leishmaniasis is an endemic disease in Iran the mucosal involvement is rare. Mucocutaneous leishmaniasis (MCL) mainly caused by Leishmanial braziliensis infection, reported with other Leishmania species such as L. major.
Pedram NORMOHAMADPUR, Forugh GHAEDI
doaj  

Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection

Journal of Experimental Medicine, 2015
While people infected with Leishmania can become refractory to reinfection, human vaccines have not yet been achieved. Glennie et al. identify a population of skin-resident Leishmania-specific memory T cells that produce IFN-γ and recruit circulating T ...
Nelson D. Glennie, Venkata Yeramilli, D. Beiting, S. Volk, C. Weaver, P. Scott   +5 more
semanticscholar   +1 more source

Leishmania major Strain-Dependent Macrophage Activation Contributes to Pathogenicity in the Absence of Lymphocytes

, 2022
Jalal Alshaweesh, Risa Nakamura, Yuka Tanaka, Mizuki Hayashishita, Abu Musa, Mihoko Kikuchi, D.K. Inaoka, Shinjiro Hamano   +7 more
openalex   +1 more source

Population genetics of Leishmania (Leishmania) major DNA isolated from cutaneous leishmaniasis patients in Pakistan based on multilocus microsatellite typing

Parasites & Vectors, 2014
Background Cutaneous leishmaniasis (CL) is a major and fast increasing public health problem, both among the local Pakistani populations and the Afghan refugees in camps.
Mohammad Zahangir Alam, Abdul Manan Bhutto, Farooq Rahman Soomro, Javed Hussain Baloch, Ryo Nakao, Hirotomo Kato, Gabriele Schönian, Hiroshi Uezato, Yoshihisa Hashiguchi, Ken Katakura   +9 more
doaj   +1 more source

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes [PDF]

, 2014
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological ...
Carlow, Clotilde K. S., Chapman, Melissa S., Galvin, Brendan D., Li, Zhiru, Pollastri, Michael P., Poole, Catherine B., Villemaine, Estelle, Wyatt, Paul G.   +7 more
core   +4 more sources

Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation

Nucleic Acids Research, 2015
Protozoan parasites of the genus Leishmania are the etiological agents of leishmaniasis, a group of diseases with a worldwide incidence of 0.9–1.6 million cases per year.
Laura A. L. Dillon, Kwame Okrah, V. Hughitt, Rahul Suresh, Yuan Li, M. C. Fernandes, A. Belew, Héctor Corrada Bravo, D. Mosser, Najib M. El-Sayed   +9 more
semanticscholar   +1 more source

Characterization of NUDIX Hydrolase from Leishmania major

Acta Parasitologica
Abstract Hydrolysis of a wide range of organic pyrophosphates is carried out by a family of NUDIX hydrolases present ubiquitously in all kingdoms of life. NUDIX hydrolases have a highly conserved 23 amino acid long NUDIX box domain. When the genome sequence of Leishmania major, was analyzed for NUDIX motif, it revealed nine proteins had NUDIX ...
Mahendra D. Jamdhade, Pavan Kumar Mysuru Shivalingappa, Ashwini N. Atre, Kiran N. Mahale, Milind S. Patole, Harsh Pawar   +5 more
openaire   +1 more source

Systems analysis of host-parasite interactions. [PDF]

, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide.
Jamshidi, Neema, Lewis, Nathan E, Swann, Justine, Winzeler, Elizabeth A   +3 more
core   +1 more source