Results 81 to 90 of about 116,783 (314)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

High Cytotoxic Efficiency of Lentivirally and Alpharetrovirally Engineered CD19-Specific Chimeric Antigen Receptor Natural Killer Cells Against Acute Lymphoblastic Leukemia

Frontiers in Immunology, 2020
Autologous chimeric antigen receptor-modified (CAR) T cells with specificity for CD19 showed potent antitumor efficacy in clinical trials against relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Contrary to T cells, natural killer (NK)
Stephan Müller, Stephan Müller, Tobias Bexte, Tobias Bexte, Tobias Bexte, Veronika Gebel, Veronika Gebel, Franziska Kalensee, Franziska Kalensee, Eva Stolzenberg, Eva Stolzenberg, Jessica Hartmann, Ulrike Koehl, Ulrike Koehl, Ulrike Koehl, Axel Schambach, Axel Schambach, Winfried S. Wels, Winfried S. Wels, Winfried S. Wels, Ute Modlich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich, Evelyn Ullrich   +24 more
doaj   +1 more source

Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization. [PDF]

, 2018
Lentiviral vector mobilization following HIV-1 infection of vector-transduced cells poses biosafety risks to vector-treated patients and their communities.
Bi, Yanmin, Fry, Nate J, Hu, Peirong, Kafri, Tal, Kohn, Donald B, Ma, Hong, Suwanmanee, Thipparat, Zeithaml, Brian   +7 more
core  

The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]

, 2018
Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi, Burgoyne, Paul, Burt, Claire L., Fraser, Alasdair R., Graham, Gerard J., Hansell, Christopher A.H., Hayes, Alan J., Lee, Kit Ming, Macleod, Megan K.L., Medina-Ruiz, Laura, Nibbs, Robert J.B., Pingen, Marieke, Wilson, Gillian J.   +12 more
core   +1 more source

GPER-induced signaling is essential for the survival of breast cancer stem cells. [PDF]

, 2020
G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells.
Chan, Yu-Tzu, Chang, Wen-Wei, Chang, Wen-Ying, Chen, Yu-Ju, Lai, Alan C-Y, Lin, Ruey-Jen, Lin, Yu-Ju, Wang, Ya-Hui, Wang, Yi-Ting, Wu, Hsin-Yi, Wu, Jen-Chine, Yu, Alice L, Yu, Jyh-Cherng   +12 more
core   +2 more sources

Optimized lentiviral transduction of human amniotic mesenchymal stromal cells

Pharmacological Research, 2018
Mesenchymal stromal cells are excellent candidates for regenerative medicine since they are multipotent, easy to isolate, can be expanded to obtain clinically relevant numbers and are immunoprivileged. Stable genetic modification with viral vectors can improve mesenchymal stromal cell function and enhance their therapeutic potential.
Pisano, Federica, Mura, Manuela, Ciuffreda, Maria Chiara, Calabrò, Federica, Lanzo, Nicola, Gnecchi, Massimiliano   +5 more
openaire   +3 more sources

Derivation of Induced Pluripotent Stem Cells by Lentiviral Transduction [PDF]

, 2011
This chapter provides a method for reprogramming human dermal fibroblasts into induced pluripotent stem cells (iPSCs) using three lentiviruses containing cDNAs for OCT4 and SOX2, KLF4 and C-MYC, and NANOG and LIN28, respectively. Lentiviral vectors are based on the human immunodeficiency virus (HIV) and provide an effective means for the delivery ...
Hubert E, Nethercott, David J, Brick, Philip H, Schwartz   +2 more
openaire   +2 more sources

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Advanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri‐Zadeh, Jeff W. M. Bulte   +7 more
wiley   +1 more source

Genomic insertion of lentiviral DNA circles directed by the yeast Flp recombinase

BMC Biotechnology, 2008
Background Circular forms of viral genomic DNA are generated during infection of cells with retroviruses like HIV-1. Such circles are unable to replicate and are eventually lost as a result of cell division, lending support to the prevalent notion that ...
Yáñez-Muñoz Rafael J, Jakobsen Maria, Staunstrup Nicklas H, Moldt Brian, Mikkelsen Jacob G   +4 more
doaj   +1 more source