Results 61 to 70 of about 260,635 (281)
Lentiviral vectors for treatment of haemophilia [PDF]
, 2010 Haemophilia A and B are X‐linked recessive disorders caused by defects in coagulation factors (F) VIII and IX, respectively. Severe cases of haemophilia are characterised by episodes of spontaneous bleeding, predominantly into the joints and muscles ...
Ward, N.J.
core
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Influence of recombinant histone H1.3 on the efficiency of lentiviral transduction of human cells in vitro [PDF]
, 2012 Lentiviral vectors are widely used in genetic modification of human and animal cells (lentiviral transduction) to enhance their therapeutic potential by expression of recombinant protective and trophic factors.
Solovyeva V. +3 more
core
Lentiviral vector and transduction procedures.
, 2013 (A) Schematic diagram of Cell Genesys SIN lentiviral transfer vector pKC.MND.eGFP.neo. CMV 5′ LTR: modified cytomegalovirus 5′ long terminal repeat; RRE: rev response element; cPPT/CTS: central polypurine tract/central termination sequence; MND: myeloid ...
Sylvie Shen (371528) +4 more
core +1 more source
PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Polycomb group factor 1 (PCGF1) and coiled‐coil domain‐containing protein 34 (CCDC34) have been implicated in tumorigenesis in multiple malignancies. However, their biological functions and prognostic significance in glioma remain poorly defined.
Yuanbing Chen +7 more
wiley +1 more source
Engineering single-vector logic-gated CAR T cells with transgene sizes beyond current limitations
Journal for ImmunoTherapy of CancerBackground Engineering chimeric antigen receptor (CAR) T cells with logic-gated synthetic Notch (synNotch) receptor circuits can enhance specificity and mitigate on-target/off-tumor toxicity.
Carl H June +10 more
doaj +1 more source
The determination of importance of sequences neighboring the Psi sequence in lentiviral vector transduction and packaging efficiency. [PDF]
PLoS ONE, 2012 A number of lentiviral vector systems have been developed for gene delivery and therapy by eliminating and/or modifying viral genetic elements. However, all lentiviral vector systems derived from HIV-1 must have a viral packaging signal sequence, Psi (Ψ),
Seon Hee Kim +3 more
doaj +1 more source
Lentiviral transduction of iPSCs.
, 2013 (A) lentiviral vectors consisting of tri-fusion reporter gene; (B) lentiviral transduction of iPS with tri-fusion reporter gene and sorting of successfully transduced cells; (C) RFP expression in transduced iPSCs; (D, E), iPS cells were seeded at a ...
Xinyu Wen (3693) +12 more
core +1 more source
Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source