Results 51 to 60 of about 368,855 (303)
Driving DNA transposition by lentiviral protein transduction [PDF]
Mobile Genetic Elements, 2014 Gene vectors derived from DNA transposable elements have become powerful molecular tools in biomedical research and are slowly moving into the clinic as carriers of therapeutic genes. Conventional uses of DNA transposon-based gene vehicles rely on the intracellular production of the transposase protein from transfected nucleic acids.
Cai, Yujia, Mikkelsen, Jacob Giehm
openaire +2 more sources
Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia
Scientific Reports, 2023 Ataxia telangiectasia is a monogenetic disorder caused by mutations in the ATM gene. Its encoded protein kinase ATM plays a fundamental role in DNA repair of double strand breaks (DSBs).
Tanja Hirch +6 more
doaj +1 more source
In vitro and in vivo validation of human and goat chondrocyte labeling by green fluorescent protein lentivirus transduction [PDF]
, 2010 We investigated whether human articular chondrocytes can be labeled efficiently and for long-term with a green fluorescent protein (GFP) lentivirus and whether the viral transduction would influence cell proliferation and tissue-forming capacity.
Candrian, Christian +9 more
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JCI Insight, 2022 Lentiviral vector–based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of ...
Takuya Tada +3 more
doaj +1 more source
BMC Biotechnology, 2011 Background Monocyte-derived macrophages contribute to atherosclerotic plaque formation. Therefore, manipulating macrophage function could have significant therapeutic value.
McCoy J Philip +3 more
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Hormokines : a novel concept of plasticity in neuro-endo-immunology [PDF]
, 2006 Hormones are produced by endocrine and neuroendocrine cells and mediate mainly systemic effects. Cytokines are produced by numerous cell types and mediate local effects.
Sebök, Dalma
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Avoiding lentiviral transduction culture induced MSC senescence [PDF]
Journal of Cellular and Molecular Medicine, 2009 Dear Editor: We read with interest the recent article by Bocker and colleagues in JCMM[1]. As noted by the authors, mesenchymal stem cells (MSC) enjoy considerable therapeutic potential in regenerative medicine, cell therapy for select genetic diseases and as immunomodulators [2, 3].
Pan, Yung-Wei, Kurre, Peter
openaire +2 more sources
Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]
, 2009 Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia +23 more
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Revista Colombiana de Ciencias Pecuarias, 2019 Background: Production of transgenic animals is still a low-efficiency biotechnology, and simple alternatives should be used to improve the rate of transgenic bovine production by nuclear transfer.
Alinne G. Curcio +5 more
doaj +1 more source
Lentiviral transduction of iPSCs. [PDF]
, 2013 (A) lentiviral vectors consisting of tri-fusion reporter gene; (B) lentiviral transduction of iPS with tri-fusion reporter gene and sorting of successfully transduced cells; (C) RFP expression in transduced iPSCs; (D, E), iPS cells were seeded at a ...
Xinyu Wen (3693) +12 more
core +1 more source