Results 31 to 40 of about 247,262 (289)
Visualization of targeted transduction by engineered lentiviral vectors [PDF]
Gene Therapy, 2008 We have reported a method to target lentiviral vectors to specific cell types. This method requires the incorporation of two distinct molecules on the viral vector surface: one is an antibody that renders the targeting specificity for the engineered vector, and the other is a fusogenic protein that allows the engineered vector to enter the target cell.
K-I, Joo, P, Wang
openaire +2 more sources
Expression of a large coding sequence: Gene therapy vectors for Ataxia Telangiectasia
Scientific Reports, 2023 Ataxia telangiectasia is a monogenetic disorder caused by mutations in the ATM gene. Its encoded protein kinase ATM plays a fundamental role in DNA repair of double strand breaks (DSBs).
Tanja Hirch +6 more
doaj +1 more source
Driving DNA transposition by lentiviral protein transduction [PDF]
Mobile Genetic Elements, 2014 Gene vectors derived from DNA transposable elements have become powerful molecular tools in biomedical research and are slowly moving into the clinic as carriers of therapeutic genes. Conventional uses of DNA transposon-based gene vehicles rely on the intracellular production of the transposase protein from transfected nucleic acids.
Cai, Yujia, Mikkelsen, Jacob Giehm
openaire +2 more sources
Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]
, 2012 We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C. +10 more
core +1 more source
JCI Insight, 2022 Lentiviral vector–based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of ...
Takuya Tada +3 more
doaj +1 more source
BMC Biotechnology, 2011 Background Monocyte-derived macrophages contribute to atherosclerotic plaque formation. Therefore, manipulating macrophage function could have significant therapeutic value.
McCoy J Philip +3 more
doaj +1 more source
Restriction of HIV-1 replication in monocytes is abolished by Vpx of SIVsmmPBj [PDF]
, 2009 Background: Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors.
Kaiser, Julia +23 more
core +2 more sources
Stem Cell Research, 2015 Understanding how to achieve efficient transduction of hematopoietic stem and progenitor cells (HSPCs), while preserving their long-term ability to self-reproduce, is key for applying lentiviral-based gene engineering methods.
Duo Li +8 more
doaj +1 more source
Hormokines : a novel concept of plasticity in neuro-endo-immunology [PDF]
, 2006 Hormones are produced by endocrine and neuroendocrine cells and mediate mainly systemic effects. Cytokines are produced by numerous cell types and mediate local effects.
Sebök, Dalma
core +1 more source