Results 11 to 20 of about 1,111,723 (286)
Advances of Lentiviral Vectors
Chinese Journal of Lung Cancer, 2014 Lentiviral vectors are currently very effective tools in molecular and cell experiment. Lentiviral vector, a kind of retroviral vectors, has a number of unique advantages in target gene transferation, for example, the ability of transfection to the ...
Fanrong MENG +3 more
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Toward Personalized Gene Therapy: Characterizing the Host Genetic Control of Lentiviral-Vector-Mediated Hepatic Gene Delivery [PDF]
Molecular Therapy: Methods & Clinical Development, 2017 The success of lentiviral vectors in curing fatal genetic and acquired diseases has opened a new era in human gene therapy. However, variability in the efficacy and safety of this therapeutic approach has been reported in human patients.
Thipparat Suwanmanee +6 more
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Large-scale production of lentiviral vector in a closed system hollow fiber bioreactor [PDF]
Molecular Therapy: Methods & Clinical Development, 2015 Lentiviral vectors are widely used in the field of gene therapy as an effective method for permanent gene delivery. While current methods of producing small scale vector batches for research purposes depend largely on culture flasks, the emergence and ...
Jonathan Sheu +7 more
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Comparison of lentiviral vector titration methods [PDF]
BMC Biotechnology, 2006 Background Lentiviral vectors are efficient vehicles for stable gene transfer in dividing and non-dividing cells. Several improvements in vector design to increase biosafety and transgene expression, have led to the approval of these vectors for use in ...
Debyser Zeger +4 more
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Journal of Biomedical Science, 2004 Vectors based on lentiviruses have reached a state of development such that clinical studies using these agents as gene delivery vehicles have now begun. They have particular advantages for certain in vitro and in vivo applications especially the unique capability of integrating genetic material into the genome of non-dividing cells.
Andrew M L, Lever +2 more
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Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media
Molecular Therapy: Methods & Clinical Development, 2020 Lentiviral vectors are increasingly utilized in cell and gene therapy applications because they efficiently transduce target cells such as hematopoietic stem cells and T cells.
Matthew Bauler +12 more
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Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector. [PDF]
PLoS ONE, 2013 Hematopoietic stem cell gene therapy requires the use of integrating retroviral vectors in order to stably transmit a therapeutic gene to mature blood cells.
Sheng Zhou +5 more
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Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison [PDF]
, 2008 Cross-neutralization between rabies virus (RABV) and two European bat lyssaviruses (EBLV-1 and -2) was analysed using lentiviral pseudotypes as antigen vectors.
Temperton, Nigel J. +12 more
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Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]
, 2006 Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Joanne Crossley +11 more
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Molecular Therapy: Methods & Clinical Development, 2016 Hematopoietic stem cell (HSC) gene therapy using retroviral vectors has immense potential, but vector-mediated genotoxicity limits use in the clinic. Lentiviral vectors are less genotoxic than gammaretroviral vectors and have become the vector of choice ...
Elizabeth M Everson +4 more
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