Results 1 to 10 of about 199,900 (336)
Lentivirus production v1 [PDF]
, 2022 This protocol describes the production of lentiviruses to transduce HEK293T cells and has to be performed in a biosafety level 2 laboratory
Itika Saha +17 more
openalex +2 more sources
SARS-CoV-2 Neutralization Assay System using Pseudo-lentivirus
Indonesian Biomedical Journal, 2023 BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects humans' lower respiratory tracts and causes coronavirus disease-2019 (COVID-19).
Anastasia Armimi +9 more
doaj +1 more source
Human Retrovirus Genomic RNA Packaging
Viruses, 2022 Two non-covalently linked copies of the retrovirus genome are specifically recruited to the site of virus particle assembly and packaged into released particles.
Heather M. Hanson +3 more
doaj +1 more source
The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present
Viruses, 2021 The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Keiya Uriu +3 more
doaj +1 more source
Journal of Visualized Experiments, 2009 RNA interference (RNAi) is a system of gene silencing in living cells. In RNAi, genes homologous in sequence to short interfering RNAs (siRNA) are silenced at the post-transcriptional state. Short hairpin RNAs, precursors to siRNA, can be expressed using lentivirus, allowing for RNAi in a variety of cell types.
Xiaoyin, Wang, Michael, McManus
openaire +2 more sources
Restriction of lentivirus in monkeys [PDF]
Proceedings of the National Academy of Sciences, 2002 Retroviruses are able to cross species barriers and have done so many times throughout evolution. Perhaps as a consequence, dominant mechanisms have arisen to block infection by murine retroviruses in mice (restriction factor Fv1) and humans (restriction factor Ref1), as well as in other mammals.
Caroline, Besnier +2 more
openaire +2 more sources
Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2021 Surfactant protein B (SPB) deficiency is a severe monogenic interstitial lung disorder that leads to loss of life in infants as a result of alveolar collapse and respiratory distress syndrome.
Altar M. Munis +2 more
doaj +1 more source
Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]
, 2020 One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J +8 more
core +1 more source
Advances in Lentivirus Purification
Biotechnology Journal, 2020 AbstractLentiviral vectors (LVs) have been increasingly used as a tool for gene and cell therapies since they can stably integrate the genome in dividing and nondividing cells. LV production and purification processes have evolved substantially over the last decades.
Ana Sofia, Moreira +5 more
openaire +2 more sources