Results 1 to 10 of about 202,804 (290)

SARS-CoV-2 Neutralization Assay System using Pseudo-lentivirus

Indonesian Biomedical Journal, 2023
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects humans' lower respiratory tracts and causes coronavirus disease-2019 (COVID-19).
Anastasia Armimi, Afina Firdaus Syuaib, Katherine Vanya, Marselina Irasonia Tan, Dessy Natalia, David Virya Chen, Chikako Ono, Yoshiharu Matsuura, Anita Artarini, Ernawati Arifin Giri-Rachman   +9 more
doaj   +1 more source

Human Retrovirus Genomic RNA Packaging

Viruses, 2022
Two non-covalently linked copies of the retrovirus genome are specifically recruited to the site of virus particle assembly and packaged into released particles.
Heather M. Hanson, Nora A. Willkomm, Huixin Yang, Louis M. Mansky   +3 more
doaj   +1 more source

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present

Viruses, 2021
The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Keiya Uriu, Yusuke Kosugi, Jumpei Ito, Kei Sato   +3 more
doaj   +1 more source

Identification of a small molecule for enhancing lentiviral transduction of T cells

Molecular Therapy: Methods & Clinical Development, 2023
Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach, Charlotte Kay, Chris Tinworth, Florence Patel, Bryan Joosse, Jennifer Wade, Marlene Rosa do Carmo, Brian Donovan, Martijn Brugman, Claudia Montiel-Equihua, Natalie Francis   +10 more
doaj   +1 more source

A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications

Molecular Therapy: Methods & Clinical Development, 2021
Surfactant protein B (SPB) deficiency is a severe monogenic interstitial lung disorder that leads to loss of life in infants as a result of alveolar collapse and respiratory distress syndrome.
Altar M. Munis, Stephen C. Hyde, Deborah R. Gill   +2 more
doaj   +1 more source

Global prevalence and risk factors of equine infectious anemia: A systematic review and meta-analysis [PDF]

Veterinary World
Background and Aim: Equine infectious anemia (EIA) is a lentiviral disease affecting members of the Equidae family, with global distribution and significant implications for animal health and biosecurity.
Lintang Winantya Firdausy, Faisal Fikri, Arya Pradana Wicaksono, Hakan Çalışkan, Muhammad Thohawi Elziyad Purnama   +4 more
doaj   +1 more source

Gene Therapy Applications of Non-Human Lentiviral Vectors

Viruses, 2020
Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients. LVs hold notable and inherent advantages over other
Altar M. Munis
doaj   +1 more source

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats—A Long-Term Study

Viruses, 2023
Feline immunodeficiency virus (FIV) is a lentivirus in the family Retroviridae that infects domestic cats resulting in an immunodeficiency disease featuring a progressive and profound decline in multiple sets of peripheral lymphocytes. Despite compelling
Brian G. Murphy, Diego Castillo, Sarah Cook, Christina Eckstrand, Samantha Evans, Ellen Sparger, Chris K. Grant   +6 more
doaj   +1 more source

Lentiviral Vectors for T Cell Engineering: Clinical Applications, Bioprocessing and Future Perspectives

Viruses, 2021
Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel (Yescarta) and most recently brexucabtagene autoleucel (Tecartus) are ...
Roman P. Labbé, Sandrine Vessillier, Qasim A. Rafiq   +2 more
doaj   +1 more source

The Inside Out of Lentiviral Vectors

Viruses, 2011
Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene ...
Stéphanie Durand, Andrea Cimarelli
doaj   +1 more source