Results 111 to 120 of about 172,662 (343)
Genes to Cells, 2015 The use of third‐generation lentiviral vectors is now commonplace in most areas of basic biology. These systems provide a fast, efficient means for modulating gene expression, but experimental design needs to be carefully considered to minimize potential
Robert F Shearer, D. Saunders
semanticscholar +1 more source
Advanced Science, EarlyView.EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo +18 more
wiley +1 more source
Detection of Replication Competent Lentivirus Using a qPCR Assay for VSV-G
Molecular Therapy: Methods & Clinical Development, 2018 Lentiviral vectors are a common tool used to introduce new and corrected genes into cell therapy products for treatment of human diseases. Although lentiviral vectors are ideal for delivery and stable integration of genes of interest into the host cell ...
Lindsey M. Skrdlant +4 more
doaj +1 more source
830. Highly Efficient and Comprehensive Gene Transfer to All Muscle Groups Necessary for the Potential Treatment of Duchenne/Becker Muscular Dystrophies Following In Utero Delivery of a Lentivirus Vector in Immuno-Competent Mice [PDF]
, 2003 openalex +1 more source
Advanced Science, EarlyView.A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun +23 more
wiley +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Lentivirus Production v1 [PDF]
, 2019 This protocol is for Lentivirus production. To see the full abstract and additional resources, visit the Addgene protocol page.
openaire +1 more source
Advanced Science, EarlyView.Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu +13 more
wiley +1 more source
Advanced Science, EarlyView.CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong +5 more
wiley +1 more source