Results 11 to 20 of about 172,662 (343)
Identification of a small molecule for enhancing lentiviral transduction of T cells
Molecular Therapy: Methods & Clinical Development, 2023 Genetic modification of cells using viral vectors has shown huge therapeutic benefit in multiple diseases. However, inefficient transduction contributes to the high cost of these therapies.
Paulina Malach +10 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2021 Surfactant protein B (SPB) deficiency is a severe monogenic interstitial lung disorder that leads to loss of life in infants as a result of alveolar collapse and respiratory distress syndrome.
Altar M. Munis +2 more
doaj +1 more source
Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly
PLoS Pathogens, 2020 Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization, leading to an immature virus particle that is formed by a protein lattice based on dimeric ...
R. Dick +12 more
semanticscholar +1 more source
Veterinarska stanica, 2023 Small ruminant lentivirus (SRLV) is a group of viruses of the Retroviridae family, shared between caprine, ovine and wild ruminants. It is responsible for a systemic infection that can affect the lungs, central nervous system, mammary gland and joints, causing chronic, insidious, and progressive diseases, seriously affecting animal health. Concurrently,
Jacob_Ferreira, João +7 more
openaire +3 more sources
Global prevalence and risk factors of equine infectious anemia: A systematic review and meta-analysis [PDF]
Veterinary WorldBackground and Aim: Equine infectious anemia (EIA) is a lentiviral disease affecting members of the Equidae family, with global distribution and significant implications for animal health and biosecurity.
Lintang Winantya Firdausy +4 more
doaj +1 more source
Gene Therapy Applications of Non-Human Lentiviral Vectors
Viruses, 2020 Recent commercialization of lentiviral vector (LV)-based cell therapies and successful reports of clinical studies have demonstrated the untapped potential of LVs to treat diseases and benefit patients. LVs hold notable and inherent advantages over other
Altar M. Munis
doaj +1 more source
Viruses, 2023 Feline immunodeficiency virus (FIV) is a lentivirus in the family Retroviridae that infects domestic cats resulting in an immunodeficiency disease featuring a progressive and profound decline in multiple sets of peripheral lymphocytes. Despite compelling
Brian G. Murphy +6 more
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OncoTargets and Therapy, 2020 Purpose Gastric cancer has a high mortality rate worldwide. Although treatments, such as molecular-targeted therapy, have been introduced, the resulting long-term survival and prognosis remain unsatisfactory.
Jong-Hyung Park +7 more
semanticscholar +1 more source
Viruses, 2021 Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel (Yescarta) and most recently brexucabtagene autoleucel (Tecartus) are ...
Roman P. Labbé +2 more
doaj +1 more source
Lentivirus-induced immune dysregulation [PDF]
Veterinary Immunology and Immunopathology, 2008 FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B, Tompkins, Wayne A, Tompkins
openaire +2 more sources