Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [PDF]
, 2009 Huntington's disease (HD) is an autosomal dominant neurodegenerative disease resulting from the expansion of a glutamine repeat in the huntingtin (Htt) protein.
Ko, Jan +2 more
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HIV Diagnosis and Treatment through Advanced Technologies
Frontiers in Public Health, 2017 Human immunodeficiency virus (HIV) is the chief contributor to global burden of disease. In 2010, HIV was the fifth leading cause of disability-adjusted life years in people of all ages and leading cause for people aged 30–44 years. It is classified as a
Hafiza Fizzah Zulfiqar +10 more
doaj +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005 Estudou-se a capacidade do vírus da artrite-encefalite dos caprinos (CAEV) infectar o feto ou o cabrito neonato pela via de transmissão transplacentária ou no momento do parto.
M.C.C.S.H. Lara +2 more
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eLife, 2019 Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the generation of functional neurons while bypassing any stem cell intermediary stages.
Joseph Herdy +9 more
doaj +1 more source
Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. [PDF]
, 2018 Cardiokines play an essential role in maintaining normal cardiac functions and responding to acute myocardial injury. Studies have demonstrated the heart itself is a significant source of C1q/TNF-related protein 9 (CTRP9). However, the biological role of
Feng, Pan +13 more
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Beyond retrovirus infection: HIV meets gene therapy
Genetics and Molecular Biology, 2006 The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA.
Flávia Helena da Silva +2 more
doaj +1 more source
Retrogradely Transportable Lentivirus Tracers for Mapping Spinal Cord Locomotor Circuits
Frontiers in Neural Circuits, 2018 Retrograde tracing is a key facet of neuroanatomical studies involving long distance projection neurons. Previous groups have utilized a variety of tools ranging from classical chemical tracers to newer methods employing viruses for gene delivery.
Imran S. Sheikh +7 more
doaj +1 more source
Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles. [PDF]
, 2018 Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those ...
Arizala, Jerlisa Ann C +5 more
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Engineering Novel Lentiviral Vectors for Labelling Tumour Cells and Oncogenic Proteins
Bioengineering, 2022 Lentiviral vectors are unique and highly efficient genetic tools to incorporate genetic materials into the genome of a variety of cells whilst conserving biosafety.
Seçkin Akgül +3 more
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microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. [PDF]
, 2017 Glycolysis was reported to have a positive correlation with radioresistance. Our previous study found that the miR-33a functioned as a tumor suppressor in malignant melanoma by targeting hypoxia-inducible factor1-alpha (HIF-1α), a gene known to promote ...
Cao, Ke +12 more
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