Results 21 to 30 of about 172,662 (343)

Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury

open access: yesJournal of Neuroinflammation, 2019
The prognosis of spinal cord injury (SCI) is closely related to secondary injury, which is dominated by neuroinflammation. There is evidence that α-synuclein aggregates after SCI and that inhibition of α-synuclein aggregation can improve the survival of ...
Hong Zeng   +8 more
semanticscholar   +1 more source

Vertical transmissibility of small ruminant lentivirus

open access: yesPLoS ONE, 2020
This study aimed to evaluate by means of Nested Polymerase Chain Reaction (nPCR), co-cultivation and sequencing, with genetic comparison between strains (mother/newborn), the occurrence of vertical transmission of Small Ruminant Lentiviruses (SRLV) from ...
Juscilânia Furtado Araújo   +10 more
semanticscholar   +1 more source

The Inside Out of Lentiviral Vectors

open access: yesViruses, 2011
Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene ...
Stéphanie Durand, Andrea Cimarelli
doaj   +1 more source

CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9

open access: yesPathogens, 2023
Herpes simplex virus type 1 (HSV-1) is a leading cause of encephalitis and infectious blindness. The commonly used clinical therapeutic drugs are nucleoside analogues such as acyclovir.
Min Ying   +9 more
doaj   +1 more source

INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes

open access: yesMolecular Therapy: Methods & Clinical Development, 2017
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman   +17 more
doaj   +1 more source

Inositol Phosphates and Retroviral Assembly: A Cellular Perspective

open access: yesViruses, 2021
Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
doaj   +1 more source

HIV Diagnosis and Treatment through Advanced Technologies

open access: yesFrontiers in Public Health, 2017
Human immunodeficiency virus (HIV) is the chief contributor to global burden of disease. In 2010, HIV was the fifth leading cause of disability-adjusted life years in people of all ages and leading cause for people aged 30–44 years. It is classified as a
Hafiza Fizzah Zulfiqar   +10 more
doaj   +1 more source

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

open access: yesJournal of Neuroinflammation, 2017
Recent evidence has suggested that peripheral inflammatory responses induced by lipopolysaccharides (LPS) play an important role in neuropsychiatric dysfunction in rodents.
Mengmeng Li   +8 more
semanticscholar   +1 more source

Possibility of vertical transmission of caprine arthritis-encephalitis virus in neonate kids Possibilidade de transmissão vertical do vírus da artrite-encefalite dos caprinos em cabritos

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia, 2005
Estudou-se a capacidade do vírus da artrite-encefalite dos caprinos (CAEV) infectar o feto ou o cabrito neonato pela via de transmissão transplacentária ou no momento do parto.
M.C.C.S.H. Lara   +2 more
doaj   +1 more source

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