Results 31 to 40 of about 122,780 (298)
Viruses, 2021 Lentiviral vectors have played a critical role in the emergence of gene-modified cell therapies, specifically T cell therapies. Tisagenlecleucel (Kymriah), axicabtagene ciloleucel (Yescarta) and most recently brexucabtagene autoleucel (Tecartus) are ...
Roman P. Labbé +2 more
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Development of Viral Vectors for Use in Cardiovascular Gene Therapy
Viruses, 2010 Cardiovascular disease represents the most common cause of mortality in the developed world but, despite two decades of promising pre-clinical research and numerous clinical trials, cardiovascular gene transfer has so far failed to demonstrate convincing
Paul A. Kingston +3 more
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The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present
Viruses, 2021 The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses.
Keiya Uriu +3 more
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A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution [PDF]
Proceedings of the National Academy of Sciences, 2008 Lentiviruses chronically infect a broad range of mammalian species and have been transmitted from primates to humans, giving rise to multiple outbreaks of HIV infection over the past century. Although the circumstances surrounding these recent zoonoses are becoming clearer, the nature and timescale of interaction between lentiviruses and ...
Gifford, R +5 more
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Human Retrovirus Genomic RNA Packaging
Viruses, 2022 Two non-covalently linked copies of the retrovirus genome are specifically recruited to the site of virus particle assembly and packaged into released particles.
Heather M. Hanson +3 more
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INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
Molecular Therapy: Methods & Clinical Development, 2017 Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy.
Eric Sherman +17 more
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Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
Viruses, 2021 Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been ...
Clifton L. Ricaña, Robert A. Dick
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Lentivirus-induced immune dysregulation [PDF]
Veterinary Immunology and Immunopathology, 2008 FIV/HIV infections are associated with an early robust humoral and cellular anti-viral immune response followed by a progressive immune suppression that eventually results in AIDS. Several mechanisms responsible for this immune dysfunction have been proposed including cytokine dysregulation, immunologic anergy and apoptosis, and inappropriate ...
Mary B. Tompkins, Wayne A. F. Tompkins
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HIV Diagnosis and Treatment through Advanced Technologies
Frontiers in Public Health, 2017 Human immunodeficiency virus (HIV) is the chief contributor to global burden of disease. In 2010, HIV was the fifth leading cause of disability-adjusted life years in people of all ages and leading cause for people aged 30–44 years. It is classified as a
Hafiza Fizzah Zulfiqar +10 more
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Engineering Novel Lentiviral Vectors for Labelling Tumour Cells and Oncogenic Proteins
Bioengineering, 2022 Lentiviral vectors are unique and highly efficient genetic tools to incorporate genetic materials into the genome of a variety of cells whilst conserving biosafety.
Seçkin Akgül +3 more
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