CREB is a critical regulator of normal hematopoiesis and leukemogenesis [PDF]
, 2008 The cAMP-responsive element binding protein (CREB) is a 43-kDa nuclear transcription factor that regulates cell growth, memory, and glucose homeostasis. We showed previously that CREB is amplified in myeloid leukemia blasts and expressed at higher levels
Akashi +55 more
core +3 more sources
Comparison of immunoassay and real-time PCR methods for the detection of Jembrana disease virus infection in Bali cattle [PDF]
, 2009 A sensitive diagnostic assay for the detection of infections with the bovine lentivirus Jembrana disease virus (JDV) is required in Indonesia to control the spread of Jembrana disease. Immunoassays are used routinely but are compromised by cross-reactive
Desport, M. +5 more
core +2 more sources
Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]
, 2010 TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis +62 more
core +9 more sources
Retrogradely Transportable Lentivirus Tracers for Mapping Spinal Cord Locomotor Circuits
Frontiers in Neural Circuits, 2018 Retrograde tracing is a key facet of neuroanatomical studies involving long distance projection neurons. Previous groups have utilized a variety of tools ranging from classical chemical tracers to newer methods employing viruses for gene delivery.
Imran S. Sheikh +7 more
doaj +1 more source
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]
, 2017 Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo +90 more
core +2 more sources
An endogenous lentivirus in the germline of a rodent
Retrovirology, 2022 AbstractLentiviruses (genus Lentivirus) are complex retroviruses that infect a broad range of mammals, including humans. Unlike many other retrovirus genera, lentiviruses have only rarely been incorporated into the mammalian germline. However, a small number of endogenous retrovirus (ERV) lineages have been identified, and these rare genomic “fossils ...
Roziah Kambol +2 more
openaire +3 more sources
SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway. [PDF]
, 2018 SIRT3 is a class III histone deacetylase that modulates energy metabolism, genomic stability and stress resistance. It has been implicated as a potential therapeutic target in a variety of neurodegenerative diseases, including Parkinson's disease (PD ...
Deng, Yong-Ning +6 more
core +1 more source
Engineering Novel Lentiviral Vectors for Labelling Tumour Cells and Oncogenic Proteins
Bioengineering, 2022 Lentiviral vectors are unique and highly efficient genetic tools to incorporate genetic materials into the genome of a variety of cells whilst conserving biosafety.
Seçkin Akgül +3 more
doaj +1 more source
Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]
, 2014 The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis +1 more
core +4 more sources
Retroviral Integration Site Selection
Viruses, 2010 The stable insertion of a copy of their genome into the host cell genome is an essential step of the life cycle of retroviruses. The site of viral DNA integration, mediated by the viral-encoded integrase enzyme, has important consequences for both the ...
Angela Ciuffi, Sébastien Desfarges
doaj +1 more source