Results 71 to 80 of about 98,106 (307)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

The zebrafish xenograft platform-A novel tool for modeling KSHV-associated diseases [PDF]

, 2019
Kaposi\u27s sarcoma associated-herpesvirus (KSHV, also known as human herpesvirus-8) is a gammaherpesvirus that establishes life-long infection in human B lymphocytes.
Berman, Jason N, Coombs, Andrew J, Dellaire, Graham, Druley, Todd E, Ha, Michael N, McCormick, Craig, Melong, Nicole, O\u27Leary, David, Pringle, Eric S, Robinson, Carolyn-Ann, Veinotte, Chansey, Wertman, Jaime, Young, Andrew L   +12 more
core   +2 more sources

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Cas9+ conditionally-immortalized macrophages as a tool for bacterial pathogenesis and beyond. [PDF]

, 2019
Macrophages play critical roles in immunity, development, tissue repair, and cancer, but studies of their function have been hampered by poorly-differentiated tumor cell lines and genetically-intractable primary cells.
Barton, Gregory M, Ching, Krystal L, Cox, Jeffery S, Golovkine, Guillaume, Licht, Daniel J, Mitchell, Gabriel, Popov, Lauren M, Roberts, Allison W   +7 more
core  

Diagnosing infection with small ruminant lentiviruses of genotypes A and B by combining synthetic peptides in ELISA [PDF]

, 2015
The major challenges in diagnosing small ruminant lentivirus (SRLV) infection include early detection and genotyping of strains of epidemiological interest.
Amorena Zabalza, Beatriz, Andrés, Damián F. de, Crespo, Helena, Gimeno, Marina, Glaria, Idoia, Luján, Lluís, Pinczowski, Pedro, Pérez, Marta M., Reina, Ramsés, Sanjosé, Leticia   +9 more
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 [PDF]

, 2013
SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr
A Bergamaschi, A Kirmaier, AA Compton, AA Compton, B Descours, B Kim, B Romani, Chuanping Wang, D Sauter, DC Goldstone, ES Lim, F Kirchhoff, F Re, H Lahouassa, HM Baldauf, J Ahn, J He, J Yan, Jacek Skowronski, JB Jowett, Jennifer Mehrens, Jeremy Luban, Jinwoo Ahn, K Hrecka, K Hrecka, M Anisimova, M Emerman, M Tristem, MD Daugherty, ME Rogel, MH Malim, Michael Emerman, MW McNatt, N Laguette, N Laguette, NK Duggal, Oliver I. Fregoso, PM Sharp, RC Edgar, RD Powell, RK Bradley, S Guindon, S Srivastava, SL Sawyer, T Gramberg, TE White, VM Hirsch, VM Hirsch   +47 more
core   +8 more sources

Investigation of small ruminant lentivirus infections by serological and molecular methods in eastern mediterranean region [PDF]

Eurasian Journal of Veterinary Sciences
Aim: The aim of this study was to investigate the presence of small ruminant lentivirus infections in samples taken from goat and sheep farms. Materials and Methods: In this study, leukocyte and blood serum samples were taken from a total of 700 animals,
Fırat Doğan, Veysel Soydal Ataseven, Seval Bilge Dağalp, Yaşar Ergün   +3 more
doaj  

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma [PDF]

, 2015
Immunomodulatory drugs (IMiDs) have potent anti-tumor activities in multiple myeloma (MM) and are able to enhance the cytotoxic function of natural killer (NK) cells, important effectors of the immune response against MM.
Abruzzese, MARIA PIA, Cecere, Francesca, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Peruzzi, Giovanna, Petrucci, MARIA TERESA, Ricciardi, Maria Rosaria, Santoni, Angela, Soriani, Alessandra, Vulpis, Elisabetta, Zingoni, Alessandra   +12 more
core   +2 more sources