Results 91 to 100 of about 239,997 (210)

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

Insulin elevates leptin secretion and mRNA levels via cyclic AMP in 3T3-L1 adipocytes deprived of glucose

Heliyon, 2016
Aims: Leptin plays an important role in the pathogenesis of obesity and diabetes, yet the regulatory mechanisms of this hormone have not been fully elucidated.
Tomomi Tsubai, Yukihiro Noda, Kazuma Ito, Makoto Nakao, Yusuke Seino, Yutaka Oiso, Yoji Hamada   +6 more
doaj   +1 more source

Exogenous leptin affects sperm parameters and impairs blood testis barrier integrity in adult male mice

Reproductive Biology and Endocrinology, 2018
Background Serum leptin levels are augmented in obese infertile men and in men with azoospermia. They also correlate inversely with sperm concentration, motility and normal forms.
Xiaotong Wang, Xiaoke Zhang, Lian Hu, Honggang Li   +3 more
doaj   +1 more source

Long-duration leptin transgene expression in dorsal vagal complex does not alter bone parameters in female Sprague Dawley rats

Bone Reports
The hypothalamus and dorsal vagal complex (DVC) are both important for integration of signals that regulate energy balance. Increased leptin transgene expression in either the hypothalamus or DVC of female rats was shown to decrease white adipose tissue ...
Russell T. Turner, Adam J. Branscum, Urszula T. Iwaniec   +2 more
doaj   +1 more source

The Effects of Leptin Replacement on Neural Plasticity

Neural Plasticity, 2016
Leptin, an adipokine synthesized and secreted mainly by the adipose tissue, has multiple effects on the regulation of food intake, energy expenditure, and metabolism.
Gilberto J. Paz-Filho
doaj   +1 more source

Multiple Requirements for Rab GTPases in the Development of Drosophila Tracheal Dorsal Branches and Terminal Cells

G3: Genes, Genomes, Genetics, 2020
Benedikt T. Best, Maria Leptin
doaj   +1 more source

[Leptin, leptin gene, leptin gene receptor polymorphisms and pregnancy].

Ginekologia polska, 2008
The article presents information about leptin as the major metabolic hormone. The structure, localization of the hormone and its receptor have been described focusing on maturation and fertility processes. Several polymorphisms of leptin gene and its receptor have been described as potential developmental factors of pregnancy complications such as ...
Rafał, Iciek, Ewa, Wender-Ozegowska, Agnieszka, Seremak-Mrozikiewicz, Krzysztof, Drews, Jacek, Brazert   +4 more
openaire   +1 more source

New pharmacological perspectives for the leptin receptor in the treatment of obesity

Frontiers in Endocrinology, 2014
After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure.
Clara eRoujeau, Ralf eJockers, Julie eDam   +2 more
doaj   +1 more source

Community Lynching and the US Asthma Epidemic [PDF]

, 2003
We explore the implications of IR Cohen's work on immune cognition for understanding rising rates of asthma morbidity and mortality in the US. Immune cognition is inherently linked with central nervous system cognition, and with the cognitive function ...
Fullilove, Mindy, Wallace, Deborah, Wallace, Rodrick   +2 more
core  

Childhood Obesity and Familial Hypercholesterolemia: Genetic Diseases that Contribute to Cardiovascular Disease [PDF]

, 2014
Childhood obesity occurs as the result of an imbalance between caloric intake and energy expenditure. Genetic risk factors for obesity have become an area of research due to its permanency.
Caudle, Alyssa
core   +1 more source