Results 101 to 110 of about 319,296 (404)
Associations of Abdominal Muscle Area and Radiodensity with Adiponectin and Leptin: The Multiethnic Study of Atherosclerosis. [PDF]
, 2018 ObjectiveThis study examined the associations of muscle area and radiodensity with adiponectin and leptin.MethodsA total of 1,944 participants who enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body ...
Allison, Matthew A +3 more
core +2 more sources
Leptin: Is It Thermogenic? [PDF]
Endocrine Reviews, 2019 Abstract Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons: increased food intake and decreased energy expenditure (thermogenesis). This review examines the experimental evidence for the thermogenesis component. Analysis of the data available led us to conclude that the reports indicating hypometabolism
Alexander W. Fischer +3 more
openaire +2 more sources
Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease
Arthritis &Rheumatology, EarlyView.Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler +18 more
wiley +1 more source
Heliyon, 2016 Aims: Leptin plays an important role in the pathogenesis of obesity and diabetes, yet the regulatory mechanisms of this hormone have not been fully elucidated.
Tomomi Tsubai +6 more
doaj +1 more source
Structural insights into the mechanism of leptin receptor activation
Nature Communications, 2023 Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons.
Robert A. Saxton +7 more
doaj +1 more source
, 2004 Apolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL).
Luo, Guanghua +3 more
core +3 more sources
Genetic identification of leptin neural circuits in energy and glucose homeostases
Nature, 2018 Leptin, a hormone produced in white adipose tissue, acts in the brain to communicate fuel status, suppress appetite following a meal, promote energy expenditure and maintain blood glucose stability1,2.
Jie Xu +6 more
semanticscholar +1 more source
Kinetics of Leptin Binding to the Q223R Leptin Receptor
PLoS ONE, 2014 Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans +5 more
openaire +4 more sources
Proceedings of the Nutrition Society, 1998 Fertility in mammals requires adequate nutrition and a certain reserve of metabolic fuel (Van Der Spuy, 1985). Individuals experiencing wasting diseases (e.g. insu- lin-dependent diabetes), severe dietary restriction (e.g. anorexics), or who are high-performance athletes (e.g.
Julian G. Mercer +4 more
openaire +3 more sources
Semi-Automatic Generation of Tight Binary Masks and Non-Convex Isosurfaces for Quantitative Analysis of 3D Biological Samples [PDF]
arXiv, 2020 Current in vivo microscopy allows us detailed spatiotemporal imaging (3D+t) of complete organisms and offers insights into their development on the cellular level. Even though the imaging speed and quality is steadily improving, fully-automated segmentation and analysis methods are often not accurate enough.
arxiv