Results 101 to 110 of about 273,643 (354)

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Decreased leptin concentration in neonates is associated with enhanced postnatal growth during the first year

Kaohsiung Journal of Medical Sciences, 2012
Leptin regulates maternal metabolism and fetal growth by reducing food intake and increasing energy expenditure, particularly during the third trimester.
Ling-Jen Wang, Shu-Chi Mu, I Cheng, Yi-Ling Chen, Bing-Fang Chen, Guey-Mei Jow   +5 more
doaj   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To investigate the factors associated with BWL after gastrectomy using data from the phase III trial (JCOG1001). Methods This post hoc analysis included 728 patients from the JCOG1001. The percentage of BWL (%BWL) was defined as the proportion of decrease in body weight immediately before adjuvant chemotherapy initiation compared with that
Takanobu Yamada, Yukinori Kurokawa, Junki Mizusawa, Kentaro Inoue, Yasuhiro Hasegawa, Kazuhisa Ehara, Naoki Hiki, Shusaku Tsutsui, Seiji Ito, Haruhiko Fukuda, Shuji Takiguchi, Yuichiro Doki, Narikazu Boku, Takaki Yoshikawa, Masanori Terashima, Takeshi Sano, Mitsuru Sasako   +16 more
wiley   +1 more source

Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

Frontiers in Pharmacology, 2012
Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR ...
Beatriz eGálvez-Prieto, Beatriz eSomoza, Marta eGil-Ortega, Concha eF García-Prieto, Ana ede las Heras, María eGonzález, Silvia eArribas, Isabel eAranguez, Juliane eBolbrinker, Reinhold eKreutz, Mariano eRuiz-Gayo, María S Fernández-Alfonso   +11 more
doaj   +1 more source

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

, 2006
Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.
Abbott, CR, Bloom, SR, Darch, SJ, Ghatei, MA, Jethwa, PH, Murphy, KG, Patel, SR, Semjonous, NM, Seth, A, Small, CJ, Smith, KL, Todd, JF   +11 more
core   +1 more source

Impact of Body Weight Loss During Preoperative Chemoradiotherapy on Prognosis of Patients With Lower Rectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The present study aimed to investigate the relationship between changes in body weight and composition during chemoradiotherapy, such as the psoas muscle mass index, visceral fat index, and subcutaneous fat index obtained from computed tomography images, and long‐term outcomes in rectal cancer patients.
Shinya Abe, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Yuzo Harada, Takahide Shinagawa, Soichiro Ishihara   +9 more
wiley   +1 more source

Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Journal of Physiological Investigation
Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions.
Chien-Ning Hsu, Chih-Hong Kao, Chin-Hua Yang, Ming-Te Cheng, Yu-Pao Hsu, Shinn-Gwo Hong, Chao-Ling Yao, Yu-Hsu Chen   +7 more
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Transcriptional Regulation of Neuropeptide Y Gene by Leptin and Its Effect on Feeding

Journal of Pharmacological Sciences, 2005
Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus.
Hiroshi Higuchi, Ayumi Hasegawa, Tsuyoshi Yamaguchi   +2 more
doaj   +1 more source

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source