Results 141 to 150 of about 319,296 (404)
Low birth weight leads to obesity, diabetes and increased leptin levels in adults: the CoLaus study
Cardiovascular Diabetology, 2016 BackgroundLow birth weight is associated with increased rates of obesity, insulin resistance and type 2 diabetes, but the precise mechanisms for this association remain unclear.
F. Jornayvaz +5 more
semanticscholar +1 more source
arXiv, 2014 This work performs a study of the category of complete matrix-normed spaces, called matricial Banach spaces. Many of the usual constructions of Banach spaces extend in a natural way to matricial Banach spaces, including products, direct sums, and completions.
arxiv
European Journal of Heart Failure, EarlyView.Abstract Obesity and heart failure (HF) represent two growing pandemics. In the general population, obesity affects one in eight adults and is linked with an increased risk for HF. Obesity is even more common in patients with HF, where it complicates the diagnosis of HF and is linked with worse symptoms and impaired exercise capacity. Over the past few
Gianluigi Savarese +28 more
wiley +1 more source
Leptin Induces Proliferation and Notch Expression In Pancreatic Cancer
, 2016 Pancreatic adenocarcinoma (PA) is an aggressive cancer. It develops in a way that causes almost no detectable symptoms, which leads to a rapid progression and a short survival rate.
Gonzalez-Perez, PhD, Ruben +1 more
core
Mouse circadian plasma leptin and active ghrelin rhythms under ad libitum and scheduled feeding [PDF]
, 2007 Thesis (M.S.) University of Alaska Fairbanks, 2007Light is the strongest timing cue for the circadian system, but non-photic cues can also entrain the master circadian clock, i.e., suprachiasmatic nuclei (SCN).
Wan, Haiting
core
Leptin action in normal and pathological pregnancies
Journal of Cellular and Molecular Medicine, 2017 Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication ...
A. Pérez-Pérez +8 more
semanticscholar +1 more source
European Journal of Heart Failure, EarlyView.Abstract A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart ...
Gabriele Fragasso +20 more
wiley +1 more source
Journal of Clinical Investigation, 2002 The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents. In contrast,
I. Farooqi +12 more
semanticscholar +1 more source
The homeostatic dynamics of feeding behaviour identify novel mechanisms of anorectic agents [PDF]
arXiv, 2019 Better understanding of feeding behaviour will be vital in reducing obesity and metabolic syndrome, but we lack a standard model that captures the complexity of feeding behaviour. We construct an accurate stochastic model of rodent feeding at the bout level in order to perform quantitative behavioural analysis.
arxiv
Exploration, EarlyView.Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu +5 more
wiley +1 more source