Results 181 to 190 of about 74,494 (249)

Sam68 mediates leptin signaling and action in human granulosa cells: possible role in leptin resistance in PCOS. [PDF]

Endocr Connect, 2020
Vilariño-García T, Pérez-Pérez A, Santamaría-López E, Prados N, Fernández-Sánchez M, Sánchez-Margalet V.   +5 more
europepmc   +1 more source

Acute and lifelong exercise modulate the tumorigenic potential of human lung cancer cells and their susceptibility to cisplatin

Experimental Physiology, EarlyView.
Abstract The association between higher levels of physical activity and lower cancer risk and mortality is well established. However, a causal link is yet to be proven. Recent studies showed a decrease in the proliferation rates of cultured human cancer cells when the human serum used to stimulate them was conditioned by acute exercise. Here, we tested
Carlos M. Soares, João P. Moura, Leonardo M. R. Ferreira, Ana Pedrosa, Pedro Filipe, Luís Rama, Ana M. Teixeira, Ana M. Urbano   +7 more
wiley   +1 more source

Acupoints catgut embedding recovers leptin resistance via improving autophagy progress mediated by AMPK-mTOR signaling in obese mice. [PDF]

Heliyon
Xiong Y, Wang X, Gong M, Ji Q, Li Y, Hu A, Lu M, Xu B.   +7 more
europepmc   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Effect of Indian gooseberry extract on improving methylglyoxal-associated leptin resistance in peripheral tissues of high-fat diet-fed rats. [PDF]

J Food Drug Anal
Chen SY, Huang YN, Lin JA, Yen GC.
europepmc   +1 more source

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

The Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet, Johannes Burtscher, Hannes Gatterer, Katharina Hüfner, Samuel Verges, Tadej Debevec, Martin Burtscher   +6 more
wiley   +1 more source

Consuming sucrose solution promotes leptin resistance and site specifically modifies hypothalamic leptin signaling in rats.

Am J Physiol Regul Integr Comp Physiol, 2021
Harris RBS.
europepmc   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Serum Bone‐, Muscle‐ and Fat‐ Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Aims This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. Materials and Methods This study included 26 men with normal weight and 78 men with obesity.
Xiang Chen, Sumin Shen, Mingxi Zou, Zhenlin Zhang, Nanwei Tong, Juan Li   +5 more
wiley   +1 more source