Results 201 to 210 of about 74,494 (249)

Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus. [PDF]

J Pineal Res, 2019
Buonfiglio D, Tchio C, Furigo I, Donato J, Baba K, Cipolla-Neto J, Tosini G.   +6 more
europepmc   +1 more source

The Postprandial Chronobiome in Interorgan Glucose Homeostasis

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
The postprandial chronobiome framework proposes that meal‐timed oscillations in microbial communities and metabolites may interact with host tissue clocks to shape glucose handling. The liver is the best‐supported temporal interpreter, while phase‐aware human studies are needed to establish causal interorgan effects.
Josko Bozic, Roko Santic, Marko Kumric
wiley   +1 more source

Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. [PDF]

Nutrients, 2019
Torres DJ, Pitts MW, Hashimoto AC, Berry MJ.   +3 more
europepmc   +1 more source

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 345-356, August 2026.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Vector‐based comparison as a novel framework for assessing multi‐endpoint clinical trials: Applications to actual data

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Multi‐endpoint clinical trials face long‐standing statistical challenges. Vector‐based comparison (VBC) decomposes endpoints into orthogonal components. Applied to five clinical trials, it reduced confidence‐interval widths by about 50%, indicating higher statistical power, without altering the clinical meaning of endpoints.
Maria Kokkali, Vangelis D. Karalis
wiley   +1 more source

Selected monosaccharides in cancer: Metabolic routing, post‐translational modification, immunity and therapeutic potential

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Glucose, galactose, mannose and fructose can either fuel or fight tumours by rewiring metabolism and immunity. Their context‐dependent double‐edged nature suggests that precisely targeted monosaccharide interventions could become a new pillar of precision oncology.
Qin Ouyang, Ke Gao, Haojie Lu, Shu Zhang
wiley   +1 more source

Therapeutic Potential of Water‐Based Anatolian Propolis Extract Against CAF Diet‐Induced Obesity and Its Metabolic Complications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Water‐based Anatolian propolis extract attenuates CAF diet‐induced obesity‐related metabolic disturbances by improving dyslipidemia, hepatic injury, adipokine imbalance, and inflammatory status in C57BL/6 mice. ABSTRACT This study investigates the anti‐obesity effects of water‐based Anatolian propolis extract in mice with a cafeteria diet‐induced ...
Mehmet Kemal, Elif Şahin, Ali Kulaber, Sevil Kör, Ahmet Alver, Engin Yenilmez, Sevgi Kolaylı   +6 more
wiley   +1 more source

The Gut Microbiome and Diet Interact to Dictate Personalized Response to Broccoli Sprout Consumption

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The study investigated how diet, the gut microbiome, and their interactions influence the production of different types of sulforaphane metabolites, specifically bioactive (have health benefits) and inert (do not have health benefits). Mediation analysis explored these tripartite relationships.
Alexandra Alexiev, Laura M. Beaver, John A. Bouranis, Carmen P. Wong, Jan F. Stevens, Thomas J. Sharpton, Emily Ho   +6 more
wiley   +1 more source

Investigating the Association Between Anemia and Biochemical Factors in Relation to New Anthropometric Metrics in an Iranian Cohort: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Obesity has become one of the most significant health issues worldwide, and the relationship between obesity and anemia remains controversial. This study aims to assess the relationship between lipid‐based obesity parameters, new anthropometric indices, and anemia in the Kurdish population of Iran. Methods 9810 participants
Maryam Kohsari, Zohreh Rahimi, Mehdi Moradinazar   +2 more
wiley   +1 more source

Sex‐Specific Anti‐Inflammatory Effects of Alternate Day Fasting via TLR4 and Leptin Signaling in Middle‐Aged Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ADF downregulates TLR4, reducing hypothalamic and hepatic inflammation, with stronger effects in females. ADF enhances leptin sensitivity in aging by reducing SOCS3 and upregulating ObRb, thereby improving metabolic function. ADF reduces retroperitoneal fat and glucose levels, with females experiencing greater fat loss.
Ozgen Kilic‐Erkek, Gulsah Gundogdu, Abdullah Coguplugil, Yavuz Dodurga   +3 more
wiley   +1 more source