Results 211 to 220 of about 74,494 (249)
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
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MedComm, Volume 7, Issue 8, August 2026.Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong +6 more
wiley +1 more source
MedComm, Volume 7, Issue 8, August 2026.Obstructive sleep apnea (OSA) is characterized by recurrent upper‐airway collapse, which generates key nocturnal stressors including intermittent hypoxia, sleep fragmentation, intrathoracic pressure stress, and sympathetic activation. These physiological disturbances converge on shared biological mechanisms, including oxidative stress, inflammation ...
Nhi Ho Thi Thuy +8 more
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Leptin in normal physiology and leptin resistance
Science Bulletin, 2016Since the discovery of leptin as an adipokine in 1994, much progress has been made in the research about leptin. Circulating leptin binds to leptin receptor, activates STAT3-dependent and STAT3-independent signaling pathways, and plays an effective role in energy homeostasis, neuroendocrine function and metabolism mainly through acting on the central ...
Shufen Li
exaly +2 more sources
Mechanisms of Leptin Action and Leptin Resistance
Annual Review of Physiology, 2008The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity ...
Martin G, Myers +2 more
openaire +2 more sources
2018
Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid
Jiarui, Liu +3 more
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Leptin is an adipocyte-derived hormone, which contributes to the homeostatic regulation of energy balance and metabolism through humoral and neural pathways. Leptin acts on the neurons in certain brain areas such as the hypothalamus, hippocampus, and brain stem to regulate food intake, thermogenesis, energy expenditure, and homeostasis of glucose/lipid
Jiarui, Liu +3 more
openaire +2 more sources
Appetite, 2007
We consistently find that peripheral infusions of physiological doses of leptin inhibit lipogenesis in leptin-responsive animals. This study determined which aspect of leptin response was lost in fully and partially leptin-resistant animals. Male Wistar rats consumed a low-fat (LF, 10%) or high-fat (HF, 60%) diet for 3 months to generate diet induced ...
D.M. Penn, R.B.S Harris
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We consistently find that peripheral infusions of physiological doses of leptin inhibit lipogenesis in leptin-responsive animals. This study determined which aspect of leptin response was lost in fully and partially leptin-resistant animals. Male Wistar rats consumed a low-fat (LF, 10%) or high-fat (HF, 60%) diet for 3 months to generate diet induced ...
D.M. Penn, R.B.S Harris
openaire +1 more source