Results 191 to 200 of about 72,689 (297)

Sex‐dependent effects of a high‐fat diet‐induced obesity model on cerebrovascular health and brain metabolism

Experimental Physiology, EarlyView.
Abstract Mid‐life obesity is a major risk factor for neurodegenerative diseases, with mitochondrial and cerebrovascular dysfunction considered key mediators. Lysine acetylation is a reversible post‐translational modification that regulates several mitochondrial metabolic and biochemical processes.
Nicole N. Eminhizer, Dena Lin, Alec Hanshew, Jackson Stewart, Steven Ball, Christa Lilly, Saina S. Prabhu, Kate Karelina, Eric E. Kelley, Randy W. Bryner, Dharendra Thapa, Paul D. Chantler   +11 more
wiley   +1 more source

Lack of maternal exposure to somatostatin leads to diet-induced insulin and leptin resistance in mouse male offspring. [PDF]

J Mol Endocrinol
Yang Z, Kirschke CP, Huang L.
europepmc   +1 more source

CB₁R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance. [PDF]

Elife, 2020
Drori A, Gammal A, Azar S, Hinden L, Hadar R, Wesley D, Nemirovski A, Szanda G, Salton M, Tirosh B, Tam J.   +10 more
europepmc   +1 more source

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit [PDF]

, 2018
Heiko Löhr, Simon Heß, Mafalda M.A. Pereira, Philip Reinoß, Sandra Leibold, Christel Schenkel, Claudia M. Wunderlich, Peter Kloppenburg, Jens C. Brüning, Matthias Hammerschmidt   +9 more
openalex   +1 more source

Obesity-Associated Leptin Signaling Promotes Chemotherapy Resistance in Basal-Like Breast Cancer: The Role of Tumor-Associated Macrophages

, 2020
Laura W. Bowers, Aneesha Kulkarni, Stephen D. Hursting   +2 more
openalex   +1 more source

Early adversity and the comorbidity between metabolic disease and psychopathology

The Journal of Physiology, EarlyView.
Abstract figure legend Hierarchical diagram representing the interplay between the genetic background and early life adversities and its effect on multiple physiological processes that ultimately impact on the risk for the comorbdity between psychopathology and cardiometabolic disorders.
Ameyalli Gómez‐Ilescas, Patricia Pelufo Silveira   +1 more
wiley   +1 more source

Glial cells in the heart: Implications for their roles in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya, Rimma Dugarova, Shefeeq M. Theparambil   +2 more
wiley   +1 more source

GLP-1RAs attenuated obesity and reversed leptin resistance partly <i>via</i> activating the microbiome-derived inosine/A2A pathway. [PDF]

Acta Pharm Sin B
Dong C, Zhou B, Zhao B, Lin K, Tian Y, Zhang R, Xie D, Wu S, Yang L.   +8 more
europepmc   +1 more source

Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats. [PDF]

Acta Pharmacol Sin, 2020
Cai BB, Lu YN, Xu M.
europepmc   +1 more source