Results 31 to 40 of about 274,618 (211)

Leptomeningeal Carcinomatosis From Carcinoma of Unknown Primary in a Young Patient: A Case Report and a Literature Review

Journal of Investigative Medicine High Impact Case Reports, 2019
Leptomeningeal carcinomatosis, leptomeningeal meningitis, or, as referred here, leptomeningeal metastasis (LM), is a rare but frequently fatal complication seen in advanced stage of cancer either locally advanced or after a metastasis of a known primary ...
Leila Moosavi MD, Carlos D’Assumpcao MD, Jonathan Bowen BSc, Arash Heidari MD, Everardo Cobos MD   +4 more
doaj   +1 more source

Leptomeningeal Metastasis: Challenges in Diagnosis and Treatment [PDF]

Current Cancer Therapy Reviews, 2011
As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and ...
Ticiana, Leal, Julie E, Chang, Minesh, Mehta, H Ian, Robins   +3 more
openaire   +2 more sources

Detection of aneuploidy in cerebrospinal fluid from patients with breast cancer can improve diagnosis of leptomeningeal metastases

, 2021
Purpose: Detection of leptomeningeal metastasis is hampered by limited sensitivities of currently used techniques: MRI and cytology of cerebrospinal fluid (CSF).
Jager, Agnes, Bindels, Eric M.J., Sleijfer, Stefan, Angus, Lindsay, Martens, John W.M., Wilting, Saskia M.; id_orcid, Van Heuvel, Irene, Jongen, Joost L.M., Deger, Teoman, Sillevis Smitt, Peter A.E., Van Den Bent, Martin J.; id_orcid, Heitzer, Ellen, De Weerd, Vanja, Kros, Johan M., Martin J. van den Bent, Teoman Deger, Lindsay Angus, John W.M. Martens, Johan M. Kros, Saskia M. Wilting, Eric M.J. Bindels, Peter A.E. Sillevis Smitt, Vanja de Weerd, Stefan Sleijfer, Ellen Heitzer, Irene van Heuvel, Agnes Jager, Joost L.M. Jongen   +27 more
core   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

Diagnosis and treatment patterns for patients with leptomeningeal metastasis from solid tumors across Europe [PDF]

, 2017
Leptomeningeal metastases are a late manifestation of systemic cancer which affects up to 10% of patients with solid tumors. Prognosis is poor, and overall survival at 1 year is only approximately 10%.
Pérez Segura, Pedro, Dieta Brandsma, Le Rhun, Emilie, Weller, Michael, Rudà, Roberta, Devos, Patrick, Brandsma, Dieta, Hoang-Xuan, Khê, Khê Hoang-Xuan, Michael Weller, Emilie Le Rhun, Roberta Rudà, Pedro Pérez Segura, Soffietti, Riccardo, Patrick Devos, Riccardo Soffietti, Weller M, Pérez Segura P, Ruda', R, Soffietti, R, Soffietti R, Hoang-Xuan K, Rudà R, Brandsma D, Le Rhun E, Devos P   +25 more
core   +1 more source

How we treat patients with leptomeningeal metastases [PDF]

, 2019
The goal of treatment of leptomeningeal metastasis is to improve survival and to maintain quality of life by delaying neurological deterioration. Tumour-specific therapeutic options include intrathecal pharmacotherapy, systemic pharmacotherapy and focal ...
Le Rhun, Emilie, van den Bent, Martin, Andratschke, Nicolaus, Weller, Michael, Le Rhun, Emilie; https://orcid.org/, Preusser, Matthias   +5 more
core   +3 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Early Hints of Metagenome Next‐Generation Sequencing and Copy Number Variations Analysis: An Occult Case of Leptomeningeal Metastasis With Rapid Cognitive Decline

Clinical Case Reports
Early detection and treatment are critical for improving the prognosis of patients with leptomeningeal metastasis. However, heterogeneous clinical manifestations, non‐specific imaging, and limited sensitivity of cerebrospinal fluid cytology posed ...
Xueqin Chen, Haotao Zheng, Taoli Wang, Ziyang Feng, Jia Wang, Yangsicheng Liu, Wenxin Qin, Fanxin Kong, Xiude Qin   +8 more
doaj   +1 more source

Leptomeningeal Carcinomatosis: A Diagnosis Challenge

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Leptomeningeal carcinomatosis (LC) in patients with disseminated cancer has a grave prognosis and limited therapeutic options. Diagnosis is delayed due to low CSF volume and scant cellularity. This quality improvement project was undertaken to evaluate the diagnostic performance of CSF cytology in cases with radiologic evidence and ...
Makayla Hyde, Christine F. Lauro, Aaron McConeghey, Laurentia Nodit   +3 more
wiley   +1 more source