Results 61 to 70 of about 274,618 (211)

The Underlying Biology and Therapeutic Vulnerabilities of Leptomeningeal Metastases in Adult Solid Cancers

, 2021
Metastasis to the central nervous system occurs in approximately 20% of patients with advanced solid cancers such as lung cancer, breast cancer, and melanoma.
Peter M. Siegel, Stephanie Lam, Marie-Christine Guiot, Theresa Degenhard, Matthew Dankner, Livia Garzia, Kevin Petrecca   +6 more
core   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Leptomeningeal metastasis from malignant pleural mesothelioma

, 2004
Leptomeningeal metastasis from malignant mesothelioma is very rare; to our knowledge, only one imaging report exists in the literature. We present the case of widespread leptomeningeal lesions secondary to a malignant mesothelioma in a 61-year-old ...
Semnic R.R., Djilas-Ivanovic D., Sener R.N., Petrovic B.D., Kozic D.B., Prvulovic M., Klem I.   +6 more
core  

Follicular Lymphoma Presenting with Leptomeningeal Disease [PDF]

, 2014
Follicular lymphoma is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Central nervous system metastasis is a very rare complication portending a very poor prognosis. We report a rare case of follicular
Renata Costa, Ricardo Costa, Rubens Costa   +2 more
core   +1 more source

Chinese expert consensus on the diagnosis and treatment of leptomeningeal metastasis from breast cancer

Zhongguo aizheng zazhi
Leptomeningeal metastasis from breast cancer is one of the severe complications of advanced breast cancer, characterized by complex and variable clinical manifestations, rapid disease progression, and an extremely poor prognosis.
Clinical Cancer Research Evaluation Committee of Chinese Medical Education Association, Cancer Drug Clinical Research Committee of Shanghai Anti-Cancer Association   +1 more
doaj   +2 more sources

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients—A Multicenter Retrospective Cohort Study

International Journal of Cancer, Volume 159, Issue 10, Page 2562-2574, 15 November 2026.
While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva, Jacopo Bellomo, Meltem Gönel, Vittorio Stumpo, Victor Egon Staartjes, Flavio Vasella, Kevin Akeret, André Sagerer, Anna Maria Zeitlberger, David Wasilewski, Christopher Krämer, Sven König, Julia Onken, Tareq Juratli, Alexander Köpp, Regina Reimann, Marcus Czabanka, Peter Vajkoczy, Ilker Y. Eyüpoglu, Oliver Bozinov, Michael Weller, Emilie Le Rhun, Luca Regli, Carlo Serra, Marian C. Neidert, Stefanos Voglis   +25 more
wiley   +1 more source

Diagnostics and Screening in Breast Cancer with Brain and Leptomeningeal Metastasis: A Review of the Literature

Brain and leptomeningeal metastases are complications of breast cancer with high rates of morbidity and mortality and have an estimated incidence of up to 30%.
Adam J. Cohen-Nowak, Virginia B. Hill, Priya Kumthekar   +2 more
core   +1 more source

Leptomeningeal Enhancement Manifesting as a Treatment- Related Change in Isocitrate Dehydrogenase-Wildtype Glioblastoma Mimicking Leptomeningeal Metastases on Contrast-Enhanced FLAIR MRI: A Case Report

Journal of the Korean Society of Radiology
Leptomeningeal metastases in isocitrate dehydrogenase (IDH)-wild-type glioblastoma (GBM) is crucial for determining patient prognosis and treatment plans.
Ji Hwan Kang, Minchul Kim, Myung Sub Kim, Myung Ho Rho, Kyung Hoon Lee, Jason Joon Bock Lee   +5 more
doaj   +1 more source

Bloomy rind sign in meningeal metastasis of lung adenocarcinoma: A case report

Radiology Case Reports
Lung cancer is one of the most common tumors linked to leptomeningeal metastasis. The diagnosis and assessment of this condition are based on cerebrospinal fluid analysis and magnetic resonance imaging (MRI), both with and without contrast.
Sanae El hasnaoui, Sahar Boulehoual, Kaouthar Benyarou, Salwa Harek, Yassine Mebrouk   +4 more
doaj   +1 more source