Results 41 to 50 of about 234,415 (300)
Estimation of Median Lethal Dose of Cypermethrin and Betacyfluthrin
, 2017 Present study was aimed to evaluate the median lethal dose (LD50) of two broadly used, type II pyrethroid pesticides Cypermethrin and Beta-cyfluthrin against Wistar albino rats. The albino rats corresponding to experimental sets were orally administrated
Prabhu Narain Saxena, Brijender Bhushan
core +1 more source
Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin [PDF]
, 2013 Background:Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels.
Barth, Holger +24 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2004 Histological and immunocytochemical investigations were performed on different organs (brain, duodenum and thymus) of mice following lethal (420 mug/kg) or sublethal (10 mug/kg) intraperitoneal injection of yessotoxin (YTX).
FRANCHINI, Antonella +3 more
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Safety assessment of the Polypodium feei root extract: Acute and subchronic studies
Toxicology Reports, 2021 This study was performed to assess the safety of the oral acute and subchronic administration of Polypodium feei root extract through acute and subchronic studies in mice and rats, respectively.
Deden Winda Suwandi +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Substrate influence median lethal dose.
, 2013 Adult midges were exposed to substrates treated with different doses (0, 108, 109, 1010 and 1011 m−2) of ‘dry’ and ‘wet’ conidia of Metarhizium anisopliae V275 at 20±1°C. Controls were not exposed to any fungus (‘0’ doses).
Tariq M. Butt (357857) +4 more
core +1 more source
Zebrafish Sensitivity to Botulinum Neurotoxins
Toxins, 2016 Botulinum neurotoxins (BoNT) are the most potent known toxins. The mouse LD50 assay is the gold standard for testing BoNT potency, but is not sensitive enough to detect the extremely low levels of neurotoxin that may be present in the serum of sensitive ...
Kamalakar Chatla +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Toxics, 2023 Psychedelics are experiencing a strong renaissance and will soon be incorporated into clinical practice. However, there is uncertainty about how much harm they can cause at what doses.
Luis Alberto Henríquez-Hernández +3 more
doaj +1 more source