Results 51 to 60 of about 234,415 (300)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Toxicity of Imidacloprid Against Melipona scutellaris (Latreille, 1811): Preliminary Risk Analysis
SociobiologyThe study aimed to evaluate the oral toxicity of the pesticide Imidacloprid Nortox 400 SC® on native bees (Melipona scutellaris) and assess the potential risk associated with visiting crops treated with this product.
Joyce Costa +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Recherche du diéthylène-glycol dans les vins
OENO One, 1985 Au début de l'année 1985, les services de contrôle autrichiens ont misà jour l'addition de diéthylène-glycol dans certains vins de ce pays. Cette fraude avait pour but essentiel de donner aux vins plus de moelleux et de rondeur, cette substance ayant un ...
Alain Bertrand
doaj +1 more source
Toxicity studies of drugs and chemicals in animals: An overview [PDF]
Bulgarian Journal of Veterinary Medicine, 2017 Toxicity study is the investigation of either short or long-term toxic effects of a drug or chemical on animals. The toxicity is dose-dependent as asserted by Paracelsus over 500 years ago.
S. Saganuwan
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
The Molecular Basis of Toxins’ Interactions with Intracellular Signaling via Discrete Portals
Toxins, 2017 An understanding of the molecular mechanisms by which microbial, plant or animal-secreted toxins exert their action provides the most important element for assessment of human health risks and opens new insights into therapies addressing a plethora of ...
Adi Lahiani +2 more
doaj +1 more source
Journal of Horticultural Sciences, 2023 Papaya is an important fruit crop of the family Caricaceae which needs the improvement in terms of virus resistance and shelf life with dwarf stature.
Navya Bhat +5 more
doaj +1 more source