Results 71 to 80 of about 234,415 (300)

Bovine Herpesvirus Type 4 (BoHV-4) Vector Delivering Nucleocapsid Protein of Crimean-Congo Hemorrhagic Fever Virus Induces Comparable Protective Immunity against Lethal Challenge in IFNα/β/γR−/− Mice Models

Viruses, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion.
Touraj Aligholipour Farzani, Katalin Földes, Alireza Hanifehnezhad, Burcu Yener Ilce, Seval Bilge Dagalp, Neda Amirzadeh Khiabani, Koray Ergünay, Feray Alkan, Taner Karaoglu, Hurrem Bodur, Aykut Ozkul   +10 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Median Oral Lethal Dose/Lethal concentration (LD₅₀/LC₅₀) of technical grade bromethalin in mammals and birds [4].

, 2019
Median Oral Lethal Dose/Lethal concentration (LD50/LC50) of technical grade bromethalin in mammals and birds [4].
Kathy M. Loftis (6475505), Richard Bauer (95338), Christopher R. Gregory (6475508), Sayed M. Hassan (1774987), Fern Van Sant (6475496), Rita McManamon (6475502), Paula G. Ciembor (6475511), Elizabeth W. Howerth (160660), Branson W. Ritchie (1879561), Drury Reavill (6475499), Mauricio Seguel (4244593)   +10 more
core   +1 more source

Protective Role of an Initial Low-Dose Septic Challenge against Lethal Sepsis in Neonatal Mice: A Pilot Study

, 2021
Neonatal sepsis is characterized by systemic bacterial invasion followed by a massive inflammatory response. At present, no therapeutic strategy has been found that significantly reduces the mortality of neonatal sepsis.
Kazumichi Fujioka, Masafumi Saito, Mariko Ashina, Masakazu Shinohara, Harunori Miyauchi, Kandai Nozu, Takumi Kido, Shigeaki Inoue, Ruka Nakasone   +8 more
core   +1 more source

Isolation of Actinomycetes Strains and their Different Levels of Resistance against Antibiotics

Journal of Pure and Applied Microbiology, 2020
This study is aimed at isolating and characterizing strains of an actinomycetes from soils. Six strains of actinomycetes were isolated from the riverside, rhizoplane and low land of Muzaffarpur district of Bihar (India).
Khwaja Salahuddin, Md. Nizamuddin Ansari, Chandan Kumar Singh, Anupama, Amit Kumar Jha, Ritisha N. Tatmiya, Syeda Fauzia Farheen Zofair   +6 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Optimal designs for dose-response models with restricted design spaces [PDF]

In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for ...
Zhu, Wei, Dette, Holger, Biedermann, Stefanie   +2 more
core  

Acute oral and dermal toxicity parameters of a drug based on D-cyphenothrin, pyriproxyfen and piperonyl butoxide in laboratory animals

Российский паразитологический журнал
The purpose of the research is to study acute oral and dermal toxicity parameters of a drug based on D-cyphenothrin, pyriproxyfen and piperonyl butoxide in laboratory animals.Materials and methods. The study insectoacaricidal drug contains D-cyphenothrin,
M. V. Arisov, E. N. Indyuhova, G. B. Arisova, D. S. Poselov, A. A. Stepanov, E. V. Poselova   +5 more
doaj   +1 more source

Therapeutic effects of Azadirachta indica A.Juss. leaves in malaria-induced male Wistar rats [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2018
Context: Azadirachta indica has long been used in herbal or folk medicine as a remedy for the treatment of malaria and the administration of herbal preparations has raised concerns on their toxicity.
Ngozi K. Achi, Chimaraoke Onyeabo, Daniel A. Nnate, Chima A. Ekeleme-Egedigwe, Igwe K. Kalu, Ikedichim C. Chibundu, Grace C. Wokoma   +6 more
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source