Results 91 to 100 of about 345,070 (206)

Review of pyronaridine anti-malarial properties and product characteristics. [PDF]

, 2012
Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria.
Arbe-Barnes, Sarah J, Borghini-Fuhrer, Isabelle, Craft, J Carl, Croft, Simon L, Duparc, Stephan, Fleckenstein, Lawrence, Rim, Han-Jong, Shin, Chang-Sik   +7 more
core   +2 more sources

The new algorithm for calculation of median lethal dose (LD₅₀) and effective dose fifty (ED₅₀) of Micrarus fulvius venom and anti-venom in mice

International Journal of Veterinary Science and Medicine, 2016
Background One million people throughout the world are bitten each year by poisonous snakes. Of this, one‐tenth died and three‐tenth suffer some forms of disabilities. In view of this, anti‐snake venoms are currently being developed against viper and colubrid snake venoms using mice.
openaire   +3 more sources

Influence of dimethyl dicarbonate on the resistance of Escherichia coli to a combined UV-Heat treatment in apple juice.

Frontiers in Microbiology, 2015
Commercial apple juice inoculated with Escherichia coli was treated with UV-C, heat (55°C) and Dimethyl Dicarbonate - DMDC (25, 50 and 75 mg/L)-, applied separately and in combination, in order to investigate the possibility of synergistic lethal effects.
Maria eGouma, Elisa eGayán, Javier eRaso, Santiago eCondón, Ignacio eAlvarez   +4 more
doaj   +1 more source

Toxicity and bioaccumulation of Cadmium, Copper and Zinc in a direct comparison at equitoxic concentrations in common carp (Cyprinus carpio) juveniles.

PLoS ONE, 2020
The individual toxicity and bioaccumulation of cadmium, copper and zinc for common carp juveniles was evaluated in a direct comparison in two experimental setups.
Vyshal Delahaut, Božidar Rašković, Marta Satorres Salvado, Lieven Bervoets, Ronny Blust, Gudrun De Boeck   +5 more
doaj   +1 more source

Calculation of complex DNA damage induced by ions

, 2011
This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be ...
Gallagher, David C., Solov'yov, Andrey V., Surdutovich, Eugene   +2 more
core   +1 more source

Several strains, one disease: experimental investigation of Vibrio aestuarianus infection parameters in the Pacific oyster, Crassostrea gigas

Veterinary Research, 2017
This study investigated oyster infection dynamics by different strains of Vibrio aestuarianus isolated before and after the apparent re-emergence of this pathogen observed in France in 2011.
Marie-Agnès Travers, Delphine Tourbiez, Leïla Parizadeh, Philippe Haffner, Angélique Kozic-Djellouli, Mohamed Aboubaker, Marcel Koken, Lionel Dégremont, Coralie Lupo   +8 more
doaj   +1 more source

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 [PDF]

, 2015
TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression of TNF receptor
Dejager, Lien, Libert, Claude, Lodens, Sofie, Puimège, Leen, Staelens, Jan, Steeland, Sophie, Timmermans, Steven, Van Hauwermeiren, Filip, Van Ryckeghem, Sara, Vandenbroucke, Roosmarijn, Vandevyver, Sofie, Vandewalle, Jolien   +11 more
core   +1 more source

Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. [PDF]

, 2013
Skin that is exposed to radiation has an impaired ability to heal wounds. This is especially true for whole-body irradiation, where even moderate nonlethal doses can result in wound-healing deficits.
Gaberman, Elena, Gorodetsky, Raphael, Levdansky, Lilia, Mackenzie, Natalia C, McBride, William H, Micewicz, Ewa D, Xie, Michael W   +6 more
core   +1 more source

Acute toxicity effects of ethylene glycol on lethal dose 50 (LD50), urine production, and histopathology change renal tubule cell in mice.

Open veterinary journal
The LD50 (lethal dose causing 50% mortality) of ethylene glycol (EG) and its associated toxicity in mice (Mus musculus) were assessed by evaluating kidney function.This study aimed to determine the acute toxicity of an oral lethal dose of 50% (LD50) of EG, also degeneration, necrosis, and inflammatory cell invasion in kidney tubules of male rats ...
Dewa Ketut Meles, Imam Mustofa, Wurlina Wurlina, Clarissa Audreylea Donova, Essi Rayareswari Hidayanti, Niluh Suwasanti, Zulfi Nur Amrina Rosyada, Aswin Rafif Khairullah, Adeyinka Oye Akintunde, Rheza Imawan Mustofa, Satriawan Wedniyanto Putra, Riza Zainuddin Ahmad, Wasito Wasito, Ricadonna Raissa   +13 more
openaire   +3 more sources

Evaluation of the Possibility of Calculating LD50 and LD10 Using a Modified Script in the R Environment

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The median lethal dose (LD50) and the low lethal dose (LD10) are critical parameters for the safety of medicinal products. Sometimes, the pharmacopoeial probit method (PM) fails to calculate the LD10 value, and the calculation result is ...
P. V. Shadrin
doaj   +1 more source