Results 41 to 50 of about 345,070 (206)

Airborne Infection with Bacillus anthracis—from Mills to Mail

Emerging Infectious Diseases, 2004
The lack of identified exposures in 2 of the 11 cases of bioterrorism-related inhalation anthrax in 2001 raised uncertainty about the infectious dose and transmission of Bacillus anthracis. We used the Wells-Riley mathematical model of airborne infection
Kevin P. Fennelly, Amy L. Davidow, Shelly L. Miller, Nancy Connell, Jerrold J. Ellner   +4 more
doaj   +1 more source

Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control

, 2019
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy.
Abolfath, Ramin, Bronk, Lawrence, Carabe, Alejandro, Grosshans, David, Helo, Yusuf, Mohan, Radhe   +5 more
core   +1 more source

Lymphatic involution and early mortality in the young chicken produced by 2.2 GeV protons [PDF]

, 1972
Young single-comb white Leghorn cockerels were subjected to single acute doses of either 2.2 GeV protons or 250 kVp X-rays. Since young chickens exposed in the lethal range die within 48 hours of exposure, an hourly tabulation of deaths was recorded for ...
Montour, J. L., Shellabarger, C. J.
core   +1 more source

Senescence in vitro and ionising radiations—the human diploid fibroblast model [PDF]

, 1981
The influence of ionising radiations on ageing is still controversial. Since Hayflick established the concept that diploid cells have finite lifespan in vitro, human diploid fibroblast (HDF) cultures have been recognised as a potent experimental model ...
A.F.G. Stevenson, Ban, Beer, Carrel, Cox, Cremer, Cristofalo, Ebeling, Finch, Fukushima, Guichard, Hayflick, Hayflick, Hayflick, Hoehn, Holliday, Holliday, Hopwood, Hug, Kaji, Kirkwood, Kirkwood, Laublin, Lima, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Macieira-Coelho, Maisin, Martin, Namba, Nicholas, Orgel, Orgel, Russ, Schneider, Schneider, Smith, Stevenson, T. Cremer, Walburg, Weismann, Williams, Wilson   +44 more
core   +1 more source

The acute toxicity of 5-thio-substituted 3-(5-bromofuran-2-yl)-4-ethyl-(4H)-1,2,4-triazole derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2015
Aim. Research of the acute toxicity of new compounds could prevent the development of compounds with high pharmacological activity, which exhibit undesirable pharmacological properties.
E. S. Pruglo, A. I. Panasenko, E. G. Knysh   +2 more
doaj   +1 more source

Lassa antiviral LHF-535 protects guinea pigs from lethal challenge

Scientific Reports, 2022
LHF-535 is a small molecule antiviral currently in development for the treatment of Lassa fever, a zoonotic disease endemic in West Africa that generates significant morbidity and mortality.
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg   +8 more
doaj   +1 more source

Infectivity decline of an RNA plant virus by increased mutagenesis supports the lethal defection model in vivo [PDF]

, 2013
Lethal mutagenesis is a new antiviral therapy based on increasing the mutation rate by using mutagenic base and nucleoside analogues whose molecular mechanisms are not fully understood.
Brichette Mieg, Isabel, Díaz Martínez, Luis, Grande-Perez, Ana   +2 more
core  

A critically ill patient after a colchicine overdose below the lethal dose: a case report

Journal of Medical Case Reports, 2018
Background Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported.
Ichiro Hirayama, Takahiro Hiruma, Yoshihiro Ueda, Kent Doi, Naoto Morimura   +4 more
doaj   +1 more source

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PDF]

, 2017
We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics.
A Baryshnikova, A Baryshnikova, A DeLean, Aaron N Chang, AE Briner, Alex N Beckett, Alex Thomas, AM Kabadi, Amanda Birmingham, Ana Bojorquez-Gomez, ASL Wong, Assen Roguev, B Vogelstein, C Laufer, Chih-Chung Kuo, CJ Lord, Dan Du, Daniel Pekin, Dongxin Zhao, F Lori, H Xu, J Shi, Jason F Kreisberg, JD Storey, Jens Luebeck, JG Doench, John Paul Shen, Katherine Licon, Kristin Klepper, KS Pollard, Kyle Salinas Sanchez, L Avery, LA Gilbert, Lei Qi, M Costanzo, M Martin, MC Bassik, MS Neshat, Nathan E Lewis, NE Sanjana, Nevan Krogan, NJ Krogan, P Mali, P Mali, Prashant Mali, R Chari, R Mani, R Srivas, Roman Sasik, S Bandyopadhyay, SR Collins, T Hart, T Horn, Trey Ideker, VG Tusher, Y Benjamini, Y Dang   +56 more
core   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source