Results 21 to 30 of about 120,091 (334)
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
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A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress. [PDF]
PLoS ONE, 2011 Bacterial type-2 (protein-protein) toxin-antitoxin (TA) modules are two-gene operons that are thought to participate in the response to stress. Previous work with Escherichia coli has led to a debate in which some investigators conclude that the modules ...
Xiangli Wu +3 more
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Oxidized ATP Protection against Anthrax Lethal Toxin [PDF]
Infection and Immunity, 2006 ABSTRACTBacillus anthracislethal toxin (LT) induces rapid lysis (<90 min) of murine macrophages from certain inbred strains. The mechanism for LT-induced cytolysis is currently unknown. We hypothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macrophage lysis could play a role in LT-mediated cytolysis and ...
Mahtab, Moayeri +3 more
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Anthrax lethal toxin suppresses murine cardiomyocyte contractile function and intracellular Ca2+ handling via a NADPH oxidase-dependent mechanism. [PDF]
PLoS ONE, 2010 OBJECTIVES: Anthrax infection is associated with devastating cardiovascular sequelae, suggesting unfavorable cardiovascular effects of toxins originated from Bacillus anthracis namely lethal and edema toxins. This study was designed to examine the direct
Machender R Kandadi +6 more
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Anthrax Lethal Toxin Induces Endothelial Barrier Dysfunction [PDF]
The American Journal of Pathology, 2005 Hemorrhage and pleural effusion are prominent pathological features of systemic anthrax infection. We examined the effect of anthrax lethal toxin (LT), a major virulence factor of Bacillus anthracis, on the barrier function of primary human lung microvascular endothelial cells.
Jason M, Warfel +2 more
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Induction of autophagy by anthrax lethal toxin [PDF]
Biochemical and Biophysical Research Communications, 2009 Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Yian Kim, Tan +5 more
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CA-074Me Protection against Anthrax Lethal Toxin [PDF]
Infection and Immunity, 2009 ABSTRACT Anthrax lethal toxin (LT) activates the NLRP1b (NALP1b) inflammasome and caspase-1 in macrophages from certain inbred mouse strains, but the mechanism by which this occurs is poorly understood. We report here that similar to several NLRP3 (NALP3, cryopyrin)-activating stimuli, LT activation of the NLRP1b inflammasome ...
Zachary L, Newman +2 more
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Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]
PLoS ONE, 2012 Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas +5 more
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A simple electroelution method for rapid protein purification: isolation and antibody production of alpha toxin from Clostridium septicum [PDF]
PeerJ, 2017 Clostridium septicum produces a number of diseases in human and farm animals which, in most of the cases, are fatal without clinical intervention. Alpha toxin is an important agent and the unique lethal virulent factor produced by Clostridium septicum ...
Lorena Vázquez-Iglesias +6 more
doaj +2 more sources
Sensitizing Anthrax Lethal Toxin-resistant Macrophages to Lethal Toxin-induced Killing by Tumor Necrosis Factor-α [PDF]
Journal of Biological Chemistry, 2003 Macrophages from different inbred mouse strains exhibit striking differences in their sensitivity to anthrax lethal toxin (LeTx)-induced cytolysis. Although LeTx-induced cytolysis of macrophages plays an important role in the outcome of anthrax infection, the sensitivity of macrophages in vitro does not correlate with in vivo susceptibility to ...
Kim, S. O. +5 more
openaire +2 more sources