Results 111 to 120 of about 370,636 (381)

A Protocol Using Compact 3D Printed Micro‐Optical Elements for Protein Identification from Low‐Intensity Amino‐Acid Raman Signals

Advanced Materials Technologies, EarlyView.
High speed Raman spectroscopy has various applications, e.g. the sequencing of proteins. However, low signal intensity coincides with the low measurement time. The study presents a protocol using only a small number of sensitive single‐photon detectors measuring optimized spectral regions.
Jannis Weinacker, Bikash Kumar Bhandari, Alba Viejo Rodriguez, Charlotte West, Francesco De Angelis, Francesco Tantussi, Nicolò Maccaferri, Nick Goldman, Martin Wegener   +8 more
wiley   +1 more source

Missense MED12 variants in 22 males with intellectual disability: From nonspecific symptoms to complete syndromes

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 135-143, January 2023., 2023
Abstract We describe the phenotype of 22 male patients (20 probands) carrying a hemizygous missense variant in MED12. The phenotypic spectrum is very broad ranging from nonspecific intellectual disability (ID) to the three well‐known syndromes: Opitz–Kaveggia syndrome, Lujan–Fryns syndrome, or Ohdo syndrome.
Nuno Maia, Nekane Ibarluzea, Mala Misra‐Isrie, Daniel C. Koboldt, Isabel Marques, Gabriela Soares, Rosário Santos, Carlo L. M. Marcelis, Riikka Keski‐Filppula, Miriam Guitart, Elisabeth Gabau Vila, April Lehman, Scott Hickey, Mari Mori, Paulien Terhal, Irene Valenzuela, Amaia Lasa‐Aranzasti, Anna Maria Cueto‐González, Brian H. Chhouk, Rebecca C. Yeh, Jennifer E. Neil, Bassam Abu‐Libde, Tjitske Kleefstra, Mariet W. Elting, Andrea Császár, Judit Kárteszi, Beáta Bessenyei, Hans van Bokhoven, Paula Jorge, Johanna M. van Hagen, Arjan P. M. de Brouwer   +30 more
wiley   +1 more source

Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial.

American Journal of Clinical Nutrition, 2014
BACKGROUND Leucine is a key amino acid involved in the regulation of skeletal muscle protein synthesis. OBJECTIVE We assessed the effect of the supplementation of a lower-protein mixed macronutrient beverage with varying doses of leucine or a mixture ...
T. Churchward-Venne, L. Breen, Danielle M Di Donato, Amy J. Hector, C. Mitchell, D. Moore, T. Stellingwerff, D. Breuillé, E. Offord, S. Baker, Stuart M Phillips   +10 more
semanticscholar   +1 more source

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering

Advanced Materials Technologies, EarlyView.
Electrospinning enables the hierarchical assembly of nanofiber‐based scaffolds for tissue engineering. However, encapsulated proteins often undergo structural changes. This study used mesoporous silica nanoparticles (MSNs) as protective carriers, mitigating protein denaturation and supporting controlled release.
Vera Citro, Marta Clerici, Matthew T. Shephard, Tina P. Dale, Aldo R. Boccaccini, Nicholas R. Forsyth   +5 more
wiley   +1 more source

Copy number variants suggest different molecular pathways for the pathogenesis of bladder exstrophy

American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 378-390, February 2023., 2023
Abstract Bladder exstrophy is a rare congenital malformation leaving the urinary bladder open in the midline of the abdomen at birth. There is a clear genetic background with chromosome aberrations, but so far, no consistent findings apart from 22q11‐duplications detected in about 2%–3% of all patients.
Agneta Nordenskjöld, Samara Arkani, Maria Pettersson, Johanna Winberg, Jia Cao, Magdalena Fossum, Magnus Anderberg, Gillian Barker, Gundela Holmdahl, Johanna Lundin   +9 more
wiley   +1 more source

Effects of intraduodenal infusion of the branched-chain amino acid leucine on ad libitum eating, gut motor and hormone functions, and glycemia in healthy men.

American Journal of Clinical Nutrition, 2015
BACKGROUND Branched-chain amino acids (BCAAs), particularly leucine, act as nutrient signals regulating protein synthesis and degradation as well as glucose metabolism.
R. Steinert, Maria F Landrock, Sina S Ullrich, S. Standfield, B. Otto, M. Horowitz, C. Feinle-Bisset   +6 more
semanticscholar   +1 more source

Structure‐Guided Engineering of Oleate Hydratase for the Synthesis of Small Chiral Alcohols without Decoy Molecule

Advanced Synthesis &Catalysis, EarlyView.
Abstract Small and chiral secondary alcohols are sought‐after compounds that are frequently used in the synthesis of biologically active compounds. However, their stereochemically correct synthesis remains a challenge for the chemical industry. Synthetic routes are restrained by multiple steps and thus low atom efficiency.
Natalie Härterich, Andreas Schneider, Philip Horz, Nicolas D. Travnicek, Bernhard Hauer   +4 more
wiley   +1 more source

Crystal structure and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-4-methylpentanoato-κ2N,O}(1,10-phenanthroline-κ2N,N′)nickel(II)

Acta Crystallographica Section E: Crystallographic Communications, 2017
In the title compound, [Ni(C13H18NO3)2(C12H8N2)], the NiII cation shows a distorted octahedral coordination environment. It is formed by two N atoms from the phenanthroline ligand, as well as two N and two O atoms belonging to two 2-[(2-hydroxybenzyl ...
Md. Serajul Haque Faizi, Necmi Dege, Sergey Malinkin   +2 more
doaj   +1 more source

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

Journal of Physiology, 2013
•  The branched‐chain amino acid (BCAA) leucine acts as both a ‘trigger’ for the initiation of protein synthesis, and as a substrate for newly synthesized protein.
D. Wilkinson, T. Hossain, D. Hill, B. Phillips, H. Crossland, J. Williams, P. Loughna, T. Churchward-Venne, L. Breen, Stuart M Phillips, T. Etheridge, J. Rathmacher, K. Smith, N. Szewczyk, P. Atherton   +14 more
semanticscholar   +1 more source

Facile Functionalization of Separator with an Amino Acid to Boost Li–S Battery Performance

Advanced Sustainable Systems, EarlyView.
This study introduces a viable bio‐approach to functionalize conventional separators using leucine‐polyacrylic acid (Leu‐PAA) via the simple soaking method. This strategy synergistically improves polysulfide trapping, regulates lithium‐ion flux, and enhances thermal and mechanical stability, leading to excellent cycling stability.
Lulu Ren, Ying Guo, Justin Zhong, Chunhua Ying, Jin Liu, Wei‐Hong Zhong   +5 more
wiley   +1 more source