Results 41 to 50 of about 19,097 (127)

Influenza A viruses and PI3K signalling

open access: yes, 2008
The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell processes.
Hale, Benjamin G.
core  

"Properties of Vibrissa follicle cells during follicle development and regeneration, and their interactions with embryonic stem cells." [PDF]

open access: yes, 2001
Follicular dermal cells possess properties that regulate induction of follicle formation, hair growth, and follicle end bulb regeneration after amputation.
Harris, Susan Jane
core  

Structural and functional studies of novel mechanisms of Lassa fever virus nucleoprotein in immune suppression, viral RNA transcription and replication

open access: yes, 2013
Lassa fever virus is one of the most dangerous viruses of arenaviridae family, causing more than 500,000 infections per year in Africa. The fatality rate for hospitalized patients is as high as 20%.
Qi, Xiaoxuan
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Mechanisms of Rejection of High Grade B cell Lymphoma in Mice [PDF]

open access: yes, 2008
The incidence of high grade B cell lymphoma in western countries has increased over the last decades. Improvement of conventional chemotherapy regimens has significantly contributed to prolonged 5-year survival rates which currently reach around 60 ...
Sukumar, Madhusudhanan
core  

The clinical and biological consequences of different FLT3 mutations in patients with AML

open access: yes, 2009
Characterisation of pathogenic markers in acute myeloid leukaemia (AML) may benefit patients through refinement of risk stratification, application of molecularly targeted therapy and improved understanding of AML biology.
Mead, A.J.
core  

An investigation of the role of the ErbB receptor family in chemotherapeutic drug resistance and invasion in human breast cancer [PDF]

open access: yes, 2002
The purpose of the work described in this thesis was to investigate the effects of upregulation of c-erbB-2 by cDNA transfection and the downregulation by ribozyme transfection on chemotherapeutic drug sensitivity, in vitro invasion, and expression of a ...
Glynn, Sharon
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The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

open access: yes, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core  

The effects of anti-IL-6 therapy in advanced ovarian cancer

open access: yes, 2010
PhDIL-6 is a pleiotropic cytokine that has a significant role in inflammatory processes. In relation to ovarian cancer biology there is emerging evidence that it mediates processes relating to tumour growth, invasion, angiogenesis and chemo-resistance ...
Coward, Jermaine
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Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]

open access: yes, 2010
A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core  

CNTF VARIANTS WITH INCREASED BIOLOGICAL POTENCY AND RECEPTOR SELECTIVITY DEFINE A FUNCTIONAL SITE OF RECEPTOR INTERACTION

open access: yes, 1995
Human CNTF is a neurocytokine that elicits potent neurotrophic effects by activating a receptor complex composed of the ligand-specific alpha-receptor subunit (CNTFR alpha) and two signal transducing proteins, which together constitute a receptor for ...
R. Laufer   +3 more
core  

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