In Vivo Gene Expression Profiling of Staphylococcus aureus during Infection Informs Design of Stemless Leukocidins LukE and -D as Detoxified Vaccine Candidates [PDF]
Microbiology Spectrum, 2023 Staphylococcus aureus is a clinically important bacterial pathogen that has become resistant to treatment with most routinely used antibiotics. Alternative strategies, such as vaccination and phage therapy, are therefore actively being investigated to ...
Andreas F. Haag +7 more
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SarS and Rot are necessary for the repression of lukED and lukSF-PV in Staphylococcus aureus [PDF]
Microbiology Spectrum, 2023 Staphylococcus aureus is an opportunistic pathogen that employs an array of different virulence factors to evade the immune system. The bi-component pore-forming leukocidins are of particular importance for their ability to target and kill phagocytes ...
Exene E. Anderson +2 more
doaj +2 more sources
Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria. [PDF]
PLoS ONE, 2017 Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S.
Hanne Amdahl +7 more
doaj +28 more sources
The cell envelope of Staphylococcus aureus selectively controls the sorting of virulence factors [PDF]
Nature Communications, 2021 The pathogen Staphylococcus aureus releases several pore-forming toxins, termed leukocidins, that kill immune cells. Here, Zheng et al. show that the retention of a leukocidin on bacterial cells and its release are modulated by lipoteichoic acid and a ...
Xuhui Zheng +6 more
doaj +2 more sources
Comparative genomics of endemic Staphylococcus aureus ST1 in New Zealand [PDF]
mSphereStaphylococcus aureus is a major zoonotic bacterial pathogen that causes a broad spectrum of human and animal diseases, including skin infections, sepsis, endocarditis, and bovine mastitis.
Emma M. Voss +12 more
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TPST2-mediated receptor tyrosine sulfation enhances leukocidin cytotoxicity and S. aureus infection [PDF]
Frontiers in Immunology, 2023 BackgroundAn essential fact underlying the severity of Staphylococcus aureus (S. aureus) infection is the bicomponent leukocidins released by the pathogen to target and lyse host phagocytes through specific binding cell membrane receptors.
Jie He +6 more
doaj +2 more sources
High Production of LukMF’ in Staphylococcus aureus Field Strains Is Associated with Clinical Bovine Mastitis [PDF]
Toxins, 2018 Staphylococcus aureus, a major cause of bovine mastitis, produces a wide range of immune-evasion molecules. The bi-component leukocidin LukMF’ is a potent killer of bovine neutrophils in vitro.
Jurriaan Hoekstra +7 more
doaj +4 more sources
The Relative Importance of Cytotoxins Produced by Methicillin-Resistant Staphylococcus aureus Strain USA300 for Causing Human PMN Destruction [PDF]
MicroorganismsStaphylococcus aureus (S. aureus) is a prominent Gram-positive bacterial pathogen that expresses numerous cytotoxins known to target human polymorphonuclear leukocytes (PMNs or neutrophils).
Tyler K. Nygaard +7 more
doaj +2 more sources
Characterisation of Staphylococcus aureus Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes lukP/Q [PDF]
ToxinsLeukocidins of Staphylococcus (S.) aureus are bicomponent toxins that form polymeric pores in host leukocyte membranes, leading to cell death and/or triggering apoptosis. Some of these toxin genes are located on prophages and are associated with specific
Stefan Monecke +18 more
doaj +2 more sources
Detection of Alpha-Toxin and Other Virulence Factors in Biofilms of Staphylococcus aureus on Polystyrene and a Human Epidermal Model. [PDF]
PLoS ONE, 2016 The ability of Staphylococcus aureus to successfully colonize (a)biotic surfaces may be explained by biofilm formation and the actions of virulence factors.
P M den Reijer +10 more
doaj +9 more sources