Results 11 to 20 of about 2,544 (194)

Characterization of a leukocidin identified in Staphylococcus pseudintermedius. [PDF]

PLoS ONE, 2018
Bacterial infections from Staphylococcus pseudintermedius are the most common cause of skin infections (pyoderma) affecting dogs. Two component pore-forming leukocidins are a family of potent toxins secreted by staphylococci and consist of S (slow) and F
Mohamed A Abouelkhair, David A Bemis, Richard J Giannone, Linda A Frank, Stephen A Kania   +4 more
doaj   +7 more sources

Studying Staphylococcal Leukocidins: A Challenging Endeavor

Frontiers in Microbiology, 2020
Staphylococcus aureus is a well-known colonizer of the human skin and nose, but also a human pathogen that causes a wide spectrum of diseases. It is well established that S.
Angelino T. Tromp, Jos A. G. van Strijp
doaj   +4 more sources

Host–Receptor Post-Translational Modifications Refine Staphylococcal Leukocidin Cytotoxicity [PDF]

Toxins, 2020
Staphylococcal bi-component pore-forming toxins, also known as leukocidins, target and lyse human phagocytes in a receptor-dependent manner. S-components of the leukocidins Panton-Valentine leukocidin (PVL), γ-haemolysin AB (HlgAB) and CB (HlgCB ...
Angelino T. Tromp, Michiel Van Gent, Joris P. Jansen, Lisette M. Scheepmaker, Anneroos Velthuizen, Carla J.C. De Haas, Kok P.M. Van Kessel, Bart W. Bardoel, Michael Boettcher, Michael T. McManus, Jos A.G. Van Strijp, Robert Jan Lebbink, Pieter-Jan A. Haas, András N. Spaan   +13 more
doaj   +4 more sources

The anti-biofilm compound 4-ethoxybenzoic acid inhibits Staphylococcus aureus virulence factor production via a putative 4EB-binding pocket in key virulence-associated proteins [PDF]

Frontiers in Microbiology
There is a need for dual action anti-virulence and anti-biofilm agents that target the opportunistic pathogen Staphylococcus aureus. Previous research determined that 0.8 mg/mL 4-ethoxybenzoic acid (4EB) reduced S.
Caroline C. Taylor, Adonis Aviles-Gonzalez, Alexander Marchesani, Christina Kiessling, Travis Patrick, Linxin Chen, Haozhe Yao, Zixuan Li, Abbie Seward, Kuk-Jeong Chin, Eric S. Gilbert   +10 more
doaj   +2 more sources

Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization [PDF]

mAbs, 2022
Staphylococcus aureus carries an exceptional repertoire of virulence factors that aid in immune evasion. Previous single-target approaches for S.
Shweta Kailasan, Ravi Kant, Madeleine Noonan-Shueh, Tulasikumari Kanipakala, Grant Liao, Sergey Shulenin, Daisy W. Leung, Richard A. Alm, Rajan P. Adhikari, Gaya K. Amarasinghe, Michael L. Gross, M. Javad Aman   +11 more
doaj   +3 more sources

Genomic insights into multidrug resistance and virulence of methicillin-resistant Staphylococcus pseudintermedius from companion animal otitis [PDF]

Frontiers in Veterinary Science
Staphylococci are major opportunistic pathogens of companion animals and an important reservoir of antimicrobial resistance genes with zoonotic relevance.
Juliana Menezes, Juliana Menezes, Manuel Rodrigues, Tiago Pinto-Lima, Tiago Pinto-Lima, Tiago Pinto-Lima, Sara Isidoro, André Meneses, André Meneses, André Meneses, André Meneses, Adriana Belas, Adriana Belas, Adriana Belas, Adriana Belas   +14 more
doaj   +2 more sources

The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interaction. [PDF]

PLoS Biology
Lipoproteins of the opportunistic pathogen Staphylococcus aureus play a crucial role in various cellular processes and host interactions. Consisting of a protein and a lipid moiety, they support nutrient acquisition and anchor the protein to the ...
Katrin Schilcher, Morgan M Severn, Christian Jenul, Young-Saeng C Avina, Rebecca A Keogh, Alexander R Horswill   +5 more
doaj   +2 more sources

Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound

mSphere, 2022
Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with high morbidity and mortality despite current standard of care. Since Staphylococcus aureus is the most common pathogen isolated from nonhealing and infected DFU,
Christine Tkaczyk, Omari Jones-Nelson, Yue Yue Shi, David E. Tabor, Lily Cheng, Tianhui Zhang, Bret R. Sellman   +6 more
doaj   +1 more source

Structural insights into Clostridium perfringens delta toxin pore formation [PDF]

, 2013
Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the
AGW Leslie, AH Nguyen, AJ McCoy, Ajit K. Basak, AL Keyburn, Andrea Motta, AP Heuck, AR Cole, B Geny, B Walker, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Jolivet-Reynaud, C Potrich, CG Savva, Christos G. Savva, CL Hatheway, Claire E. Naylor, DC Briggs, DL Theobald, DL Theobald, E Krissinel, F Meyer, G Menestrina, J Huyet, J Rossjohn, JD Pedelacq, JD Thompson, JE Alouf, Jessica Huyet, JM Cavaillon, K Yamashita, L Jayasinghe, L Song, M Fivaz, M Manich, Maryse Gibert, MD Winn, Michel R. Popoff, N Monma, N Stein, O Knapp, P Emsley, P Evans, P Gouet, PV Afonine, R Olson, RK Tweten, S De, S Schwarz, S Sonnino, V Guillet, V Steinthorsdottir, VB Chen, VT Nguyen, Y Moran, Y Tanaka   +57 more
core   +9 more sources

Identification of two neutralizing human single-chain variable fragment antibodies targeting Staphylococcus aureus alpha-hemolysin [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): The inability of the host immune system to defeat Staphylococcus aureus is due to various secreted virulent factors such as leukocidins, superantigens, and hemolysins, which interrupt the function of immune components.
Somayeh Piri-Gavgani, Mostafa Ghanei, Abolfazl Fateh, Seyed Davar Siadat, Leila Nematollahi, Fatemeh Rahimi-Jamnani   +5 more
doaj   +1 more source