Results 21 to 30 of about 2,544 (194)

Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection

open access: yesCell Reports, 2021
Summary: Skin is one of the most common sites of host immune response against Staphylococcus aureus infection. Here, through a combination of in vitro assays, mouse models, and intravital imaging, we find that S.
Jakub M. Kwiecinski   +5 more
doaj   +1 more source

Staphylococcus aureus Impairs the Function of and Kills Human Dendritic Cells via the LukAB Toxin

open access: yesmBio, 2019
Staphylococcus aureus is a human pathogen responsible for high morbidity and mortality worldwide. Recurrent infections with this bacterium are common, suggesting that S. aureus thwarts the development of sterilizing immunity. S. aureus strains that cause
Evelien T. M. Berends   +6 more
doaj   +1 more source

Novel human monoclonal antibodies targeting the F subunit of leukocidins reduce disease progression and mortality caused by Staphylococcus aureus

open access: yesBMC Microbiology, 2018
Background Staphylococcus aureus is a leading cause of Gram-positive bacterial infections worldwide; however, the treatment of S. aureus infection has become increasingly difficult due to the prevalence of methicillin-resistant S.
Chendi Jing   +8 more
doaj   +1 more source

Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides [PDF]

open access: yes, 2017
The proteinase 3 (PR3)-positive anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) granulomatosis with polyangiitis (GPA) has been associated with chronic nasal S. aureus carriage, which is a risk factor for disease relapse.
Arends, J.P.A. (Jan)   +12 more
core   +1 more source

Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes via RpiRc

open access: yesmBio, 2016
Staphylococcus aureus is a formidable human pathogen that uses secreted cytolytic factors to injure immune cells and promote infection of its host. Of these proteins, the bicomponent family of pore-forming leukocidins play critical roles in S.
Divya Balasubramanian   +11 more
doaj   +1 more source

New targets for leukocidins [PDF]

open access: yesNature Reviews Microbiology, 2019
This study shows that staphylococcal leukocidins target endothelial cells to cause host lethality.
openaire   +2 more sources

Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020

open access: yesToxins, 2021
Staphylococcus aureus generates and releases extracellular vesicles (EVs) that package cytosolic, cell-wall associated, and membrane proteins, as well as glycopolymers and exoproteins, including alpha hemolysin, leukocidins, phenol-soluble modulins ...
Xiaogang Wang   +3 more
doaj   +1 more source

Methicillin-susceptible, Doxycycline-resistant Staphylococcus aureus, Côte d’Ivoire

open access: yesEmerging Infectious Diseases, 2007
We report 2 outbreaks of Panton-Valentine leukocidin–positive, doxycycline-resistant, methicillin-susceptible Staphylococcus aureus infections in French soldiers operating in Côte d’Ivoire.
Olivier Lesens   +11 more
doaj   +1 more source

Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection. [PDF]

open access: yesPLoS ONE, 2017
The matrix proteins of Staphylococcus aureus biofilm have not been well defined. Previous efforts to identify these proteins were performed using in vitro systems.
Mei G Lei, Ravi Kr Gupta, Chia Y Lee
doaj   +1 more source

Staphylococcal Bicomponent Pore-Forming Toxins: Targets for Prophylaxis and Immunotherapy

open access: yesToxins, 2014
Staphylococccus aureus represents one of the most challenging human pathogens as well as a common colonizer of human skin and mucosal surfaces. S. aureus causes a wide range of diseases from skin and soft tissue infection (SSTI) to debilitating and life ...
M. Javad Aman, Rajan P. Adhikari
doaj   +1 more source

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