Leukocyte elastase, a1-proteinase inhibitor, and autoantibodies to neuroantigens in diagnostics of endogenous depressive disorders [PDF]
European Psychiatry, 2022 Introduction It has been suggested that the activation of systemic inflammatory response in depression is associated with inflammatory changes in the brain (neuroinflammation) and may reflect the severity of the clinical symptoms in patients ...
Z. Sarmanova +4 more
doaj +2 more sources
Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility [PDF]
Endocrine ConnectionsBackground: Semen analysis is the standard test for evaluating male fertility. However, it may not address all aspects of male infertility. This review explores the role of leukocyte elastase (LE) as a possible biomarker for male fertility by evaluating ...
Mausumi Das +6 more
doaj +2 more sources
Isolation and Characterization of Porcine Leukocyte Elastase. Leukocyte Elastase-Inhibitor Complexes in Porcine Blood, II [PDF]
Clinical Chemistry and Laboratory Medicine, 1985 Porcine leukocyte elastase was purified from granulocytes by chelating chromatography on copper chelate Sepharose and by ion exchange chromatography on CM-Sepharose. Thus an enzyme preparation with a specific activity (substrate: MeOSuc(Ala)2ProValNan) of 89.3 U/mg protein was obtained.
R. Geiger, Anna K. Junk, Marianne Jochum
+10 more sources
The hidden side of SERPINB1/Leukocyte Elastase Inhibitor.
Semin Cell Dev Biol, 2017 SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases.
Torriglia A, Martin E, Jaadane I.
europepmc +4 more sources
Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor. [PDF]
Acta Crystallogr F Struct Biol Commun, 2018 Hochscherf J +6 more
europepmc +3 more sources
Orally Bioavailable Benzisothiazolone Inhibitors of Human Leukocyte Elastase
Journal of Medicinal Chemistry, 1995 Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of cleaving many proteins, including elastin, other components of connective tissue, certain complement proteins, and receptors.
Dennis J. Hlasta +22 more
openalex +3 more sources
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component. [PDF]
Pain, 2017 Bali KK, Kuner R.
europepmc +3 more sources
Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients. [PDF]
Biores Open Access, 2020 Alexandrovski M +2 more
europepmc +3 more sources
Frontiers in Cardiovascular Medicine, 2023 AimSignal transducer and activator of transcription (STAT) signaling is critical for the pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated STAT3 (PIAS3) negatively modulates STAT3 activity, but its role in AAA ...
Weilai Fu +15 more
doaj +1 more source
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia
Scientific Reports, 2021 Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure.
Hisanori Domon +5 more
doaj +1 more source