Leukocyte elastase, a1-proteinase inhibitor, and autoantibodies to neuroantigens in diagnostics of endogenous depressive disorders [PDF]
European Psychiatry, 2022 Introduction It has been suggested that the activation of systemic inflammatory response in depression is associated with inflammatory changes in the brain (neuroinflammation) and may reflect the severity of the clinical symptoms in patients ...
Z. Sarmanova +4 more
doaj +2 more sources
Isolation and Characterization of porcine leukocyte elastase. [PDF]
Clinical Chemistry and Laboratory Medicine, 1985 Porcine leukocyte elastase was purified from granulocytes by chelating chromatography on copper chelate Sepharose and by ion exchange chromatography on CM-Sepharose. Thus an enzyme preparation with a specific activity (substrate: MeOSuc(Ala)2ProValNan) of 89.3 U/mg protein was obtained.
Geiger, Reinhard +2 more
core +9 more sources
Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility [PDF]
Endocrine ConnectionsBackground: Semen analysis is the standard test for evaluating male fertility. However, it may not address all aspects of male infertility. This review explores the role of leukocyte elastase (LE) as a possible biomarker for male fertility by evaluating ...
Mausumi Das +6 more
doaj +2 more sources
The hidden side of SERPINB1/Leukocyte Elastase Inhibitor.
Semin Cell Dev Biol, 2017 SERPINB1, also called Leukocyte Elastase Inhibitor (LEI) is a member of the clade B of SERPINS. It is an intracellular protein and acts primarily to protect the cell from proteases released into the cytoplasm during stress. Its role in inflammation is clear due to its involvement in the resolution of chronic inflammatory lung and bowel diseases.
Torriglia A, Martin E, Jaadane I.
europepmc +4 more sources
Frontiers in Cardiovascular Medicine, 2023 AimSignal transducer and activator of transcription (STAT) signaling is critical for the pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated STAT3 (PIAS3) negatively modulates STAT3 activity, but its role in AAA ...
Weilai Fu +15 more
doaj +1 more source
The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase [PDF]
Nature Medicine, 2015 Lucas Vicuña +2 more
exaly +2 more sources
Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia
Scientific Reports, 2021 Bacterial and viral respiratory infections can initiate acute lung injury and acute respiratory distress syndrome. Neutrophils and their granule enzymes, including neutrophil elastase, are key mediators of the pathophysiology of acute respiratory failure.
Hisanori Domon +5 more
doaj +1 more source
The role of plasma serine leukocyte proteinase inhibitor in the body's defense against COVID-19
Журнал микробиологии, эпидемиологии и иммунобиологии, 2021 The COVID-19 pandemic continues, causing colossal damage to the population and the global economy. As COVID-19 is studied, new data are emerging regarding the risk of severe coronavirus infection in patients with α1-antitrypsin deficiency.
A. L. Kravtsov, S. A. Bugorkova
doaj +1 more source
Correlations between different protein species of oral rinse MMP‐8 and patient‐related factors
Clinical and Experimental Dental Research, 2023 Objectives The aim of this study is to examine correlations between different oral rinse matrix metalloproteinase (MMP)‐8 protein species in western blot (WB) analysis, quantitative MMP‐8 measurements, and patient‐related factors.
Jussi M. Leppilahti +7 more
doaj +1 more source
ESTIMATION OF LEVEL OF SUBPOPULATION CD14+/CD16+ MONOCYTES IN PATIENTS WITH JUVENILE DEPRESSIONS
Медицинская иммунология, 2019 At present, at least two phenotypically different subpopulations of blood monocytes have been identified: "classical" monocytes with the phenotype CD14++/CD16- and "nonclassical" (pro-inflammatory) with the phenotype CD14+/CD16+. It has been established
E. F. Vasilyeva +5 more
doaj +1 more source